Biodegradable magnesium alloy stents (MAS) have great potential in the treatment of cardiovascular diseases. However, too fast degradation and the poor biocompatibility are still two key problems for the clinical utility of MAS. In the present work, a functional coating composed of hydrophilic polymers and bioactive peptides was constructed on magnesium alloy to improve its corrosion resistance and biocompatibility in vitro and in vivo. Mg-Zn-Y-Nd (ZE21B) alloy modified with the functional coating exhibited moderate surface hydrophilicity and enhanced corrosion resistance. The favourable hemocompatibility of ZE21B alloy with the functional coating was confirmed by the in vitro blood experiments. Moreover, the modified ZE21B alloy could selectively promote the adhesion, proliferation, and migration of endothelial cells (ECs), but suppress these behaviors of smooth muscle cells (SMCs). Furthermore, the modified ZE21B alloy wires could alleviate intimal hyperplasia, enhance corrosion resistance and re-endothelialization in vivo transplantation experiment. These results collectively demonstrated that the functional coating improved the corrosion resistance and biocompatibility of ZE21B alloy. This functional coating provides new insight into the design and development of novel biodegradable stents for biomedical engineering.

可生物降解的镁合金支架（MAS）在心血管疾病的治疗中具有巨大的潜力。然而，降解过快和生物相容性差仍然是MAS临床应用的两个关键问题。在目前的工作中，在镁合金上构建了一种由亲水聚合物和生物活性肽组成的功能涂层，以提高其在体外和体内的耐腐蚀性和生物相容性。用功能涂层改性的Mg-Zn-Y-Nd（ZE21B）合金表现出适度的表面亲水性和增强的耐腐蚀性。ZE21B合金与功能涂层的良好血液相容性通过体外实验证实血液实验。此外，改性 ZE21B 合金可以选择性地促进内皮细胞 (ECs) 的粘附、增殖和迁移，但抑制平滑肌细胞 (SMCs) 的这些行为。此外，改良的ZE21B合金丝在体内移植实验中可以减轻内膜增生，增强耐腐蚀性和再内皮化。这些结果共同表明，功能涂层提高了 ZE21B 合金的耐腐蚀性和生物相容性。这种功能性涂层为用于生物医学工程的新型可生物降解支架的设计和开发提供了新的见解。