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Recent advances in cellular optogenetics for photomedicine
Advanced Drug Delivery Reviews ( IF 16.1 ) Pub Date : 2022-07-16 , DOI: 10.1016/j.addr.2022.114457
Bing Chen 1 , Meihui Cui 2 , Yuan Wang 3 , Peng Shi 3 , Hanjie Wang 2 , Feng Wang 1
Affiliation  

Since the successful introduction of exogenous photosensitive proteins, channelrhodopsin, to neurons, optogenetics has enabled substantial understanding of profound brain function by selectively manipulating neural circuits. In an optogenetic system, optical stimulation can be precisely delivered to brain tissue to achieve regulation of cellular electrical activity with unprecedented spatio-temporal resolution in living organisms. In recent years, the development of various optical actuators and novel light-delivery techniques has greatly expanded the scope of optogenetics, enabling the control of other signal pathways in non-neuronal cells for different biomedical applications, such as phototherapy and immunotherapy. This review focuses on the recent advances in optogenetic regulation of cellular activities for photomedicine. We discuss emerging optogenetic tools and light-delivery platforms, along with a survey of optogenetic execution in mammalian and microbial cells.



中文翻译:

用于光医学的细胞光遗传学的最新进展

自从成功地将外源性光敏蛋白通道视紫红质引入神经元以来,光遗传学通过选择性地操纵神经回路,使人们能够深入了解大脑功能。在光遗传学系统中,光刺激可以精确地传递到脑组织,以在生物体中以前所未有的时空分辨率实现细胞电活动的调节。近年来,各种光致动器和新型光传输技术的发展极大地扩展了光遗传学的范围,使得能够控制非神经元细胞中的其他信号通路,用于不同的生物医学应用,例如光疗和免疫疗法。本综述侧重于光医学细胞活动的光遗传学调控的最新进展。

更新日期:2022-07-19
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