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Synergistic Poly(lactic acid) Antibacterial Surface Combining Superhydrophobicity for Antiadhesion and Chlorophyll for Photodynamic Therapy
Langmuir ( IF 3.9 ) Pub Date : 2022-07-15 , DOI: 10.1021/acs.langmuir.2c01377
Gege Wang 1 , Cao Yang 1 , Mengyao Shan 1 , Hanyu Jia 1 , Shike Zhang 1 , Xin Chen 2 , Wentao Liu 1 , Xuying Liu 1 , Jinzhou Chen 1 , Xianghong Wang 1
Affiliation  

The problem of nosocomial infections caused by bacterial growth on material surfaces is an urgent threat to public health. Although numerous materials and methods have been explored to fight against infections, the methods are complicated and the materials are slightly toxic. It is highly desirable to develop an antibacterial strategy that kills bacteria effectively without drug resistance and cytotoxicity. Herein, we present a synergistic antibacterial polylactic acid (PLA) surface with superhydrophobic antibacterial adhesion and photodynamic bactericidal activity. Initially, the surface displayed low-adhesion superhydrophobicity and resisted most bacterial adhesion. Furthermore, completely non-toxic chlorophyll possessed excellent photodynamic bactericidal properties under non-toxic visible light, which was incorporated into micro-/nanoscale PLA surfaces. We achieved efficient antibacterial activity using completely non-toxic materials and a facile non-solvent-induced phase separation process. This non-toxic, simple, good biocompatible, and no drug-resistant strategy has great advantages in combating bacterial infections.

中文翻译:

协同聚乳酸抗菌表面结合超疏水抗粘附和叶绿素光动力治疗

由材料表面细菌生长引起的医院感染问题是对公共健康的紧迫威胁。尽管已经探索了许多材料和方法来对抗感染,但方法复杂且材料具有轻微毒性。开发一种有效杀死细菌而没有耐药性和细胞毒性的抗菌策略是非常可取的。在此,我们提出了一种具有超疏水抗菌粘附和光动力杀菌活性的协同抗菌聚乳酸(PLA)表面。最初,表面显示出低粘附性超疏水性并抵抗大多数细菌粘附。此外,完全无毒的叶绿素在无毒可见光下具有优异的光动力杀菌性能,它被纳入微/纳米级 PLA 表面。我们使用完全无毒的材料和简便的非溶剂诱导相分离过程实现了有效的抗菌活性。这种无毒、简单、生物相容性好、无耐药性的策略在对抗细菌感染方面具有很大优势。
更新日期:2022-07-15
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