The flexible surface-enhanced Raman scattering (SERS) platform has ceaselessly propelled the development of point-of-care testing (POCT) in diverse fields. Herein, we report a facile strategy for the SERS-chemometric analysis of four β-blockers (bisoprolol, metoprolol, acebutolol and esmolol) based on a super-sticky mussel-inspired hydrogel SERS tape. The surface morphology and mechanical properties of the hydrogel tape can be easily controlled by adjusting the compositional ratio. The optimized tape with excellent toughness and adhesiveness allows efficient collection of analytes through a simple “paste and peel off” approach, further by spraying with silver nanoparticles using a household sprayer to instantly assemble a flexible SERS substrate, the analytes can then detected by a portable Raman spectrometer. This POCT strategy enables the identification and discrimination of four similar β-blockers with high sensitivity and accuracy in combination with the statistical algorithms. The developed SERS tape is finally utilized for the recognition of β-blockers in simulated urine solution, which realizes a limit of detection of 1.0 ng mL⁻¹, revealing a promising potential of this SERS-based POCT for the clinical detection of doping abuse.

中文翻译：

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受贻贝启发的水凝胶用于快速制造柔性 SERS 胶带，用于 β 受体阻滞剂的即时测试

灵活的表面增强拉曼散射（SERS）平台不断推动着床旁检测（POCT）在各个领域的发展。在此，我们报告了一种基于超粘性贻贝水凝胶 SERS 胶带对四种 β 受体阻滞剂（比索洛尔、美托洛尔、醋丁洛尔和艾司洛尔）进行 SERS 化学计量分析的简便策略。水凝胶胶带的表面形态和机械性能可以通过调节组成比轻松控制。具有出色韧性和粘附性的优化胶带允许通过简单的“粘贴和剥离”方法有效收集分析物，进一步通过使用家用喷雾器喷洒银纳米粒子以立即组装柔性 SERS 基板，然后可以通过便携式检测分析物拉曼光谱仪。这种 POCT 策略能够结合统计算法以高灵敏度和准确度识别和区分四种相似的 β 受体阻滞剂。开发的 SERS 胶带最终用于模拟尿溶液中 β 受体阻滞剂的识别，实现了 1.0 ng mL 的检测限^-1，揭示了这种基于 SERS 的 POCT 在临床检测兴奋剂滥用方面的潜力。