Homeobox A10 (HOXA10) encodes a transcription factor that regulates developmental processes. Whether HOXA10 mRNA levels in lower grade glioma (LGG) correlate with survival and immune cell infiltration has not been evaluated. The differential expression of HOXA10 in different tumors and their corresponding normal tissues was evaluated by exploring public datasets. The correlations between HOXA10 and survival, tumor immune cell infiltration, diverse gene mutation characteristics, and tumor mutation burden in LGG were also investigated using several independent datasets. Pathway enrichment analysis was conducted to identify HOXA10-associated signaling pathways. We found that HOXA10 expression levels did not significantly differ between LGG tumors and normal tissues. Upon assessing the association between HOXA10 expression and immune cell infiltration in LGG, as expected, HOXA10 gene mRNA levels were positively associated with B-cell and dendritic cell infiltration levels in public online datasets. Different HOXA10 expression groups showed diverse gene mutation characteristics and TMB, and low HOXA10 expression was closely related to improved LGG patient survival. Pathway enrichment analysis of HOXA10-associated genes indicated that the cell cycle signaling pathway may participate in affecting the outcomes of LGG patients. Our findings showed that HOXA10 expression was associated with LGG prognosis and tumor immunity.

同源框 A10 (HOXA10) 编码调节发育过程的转录因子。低级别胶质瘤 (LGG) 中的 HOXA10 mRNA 水平是否与存活和免疫细胞浸润相关尚未得到评估。通过探索公共数据集评估 HOXA10 在不同肿瘤及其相应正常组织中的差异表达。还使用几个独立的数据集研究了 HOXA10 与 LGG 中存活率、肿瘤免疫细胞浸润、多种基因突变特征和肿瘤突变负荷之间的相关性。进行通路富集分析以确定 HOXA10 相关信号通路。我们发现 HOXA10 表达水平在 LGG 肿瘤和正常组织之间没有显着差异。正如预期的那样，在评估 LGG 中 HOXA10 表达与免疫细胞浸润之间的关联后，HOXA10 基因 mRNA 水平与公共在线数据集中的 B 细胞和树突状细胞浸润水平呈正相关。不同的 HOXA10 表达组表现出不同的基因突变特征和 TMB，低 HOXA10 表达与 LGG 患者生存改善密切相关。HOXA10 相关基因的通路富集分析表明细胞周期信号通路可能参与影响 LGG 患者的预后。我们的研究结果表明，HOXA10 表达与 LGG 预后和肿瘤免疫相关。不同的 HOXA10 表达组表现出不同的基因突变特征和 TMB，低 HOXA10 表达与 LGG 患者生存改善密切相关。HOXA10 相关基因的通路富集分析表明细胞周期信号通路可能参与影响 LGG 患者的预后。我们的研究结果表明，HOXA10 表达与 LGG 预后和肿瘤免疫相关。不同的 HOXA10 表达组表现出不同的基因突变特征和 TMB，低 HOXA10 表达与 LGG 患者生存改善密切相关。HOXA10 相关基因的通路富集分析表明细胞周期信号通路可能参与影响 LGG 患者的预后。我们的研究结果表明，HOXA10 表达与 LGG 预后和肿瘤免疫相关。