To investigate the clinical features, treatment, and prognosis of fingolimod-associated macular edema (FAME) and to provide a reference for its rational management.

FAME-related case reports were included in a pooled analysis by searching Chinese and English databases from 2010 to November 31, 2021.

The median age of 41 patients was 50 years (range, 21, 67 years), of whom 32 were women. The median time to onset of FAME was 3 m (range.03, 120), and blurred vision (17 cases) and decreased vision (13 cases) were the most common complaints. A total of 55 eyes were involved in FAME, including the left eye (14 cases), right eye (10 cases), and both eyes (15 cases), of which 46 eyes had best-corrected visual acuity close to normal (20/12-20/60) and 8 eyes had moderate to severe visual impairment (20/80-20/500). Fundus examination in 23 patients showed macular edema (11 cases). Optical coherence tomography (OCT) in 39 patients mainly showed perifoveal cysts (24 cases), ME (23 cases), and foveal thickening (19 cases). Fundus fluorescein angiography (FFA) in 18 patients showed vascular leakage (11 cases). Complete resolution of ME occurred in 50 eyes and recovery of visual acuity occurred in 45 eyes at a median time of 2 m (range 0.25, 24) after discontinuation of fingolimod or administration of topical therapy.

Macular edema is a known complication of fingolimod. All patients using fingolimod require regular eye exams, especially those with a history of diabetes and uveitis and those undergoing cataract surgery.

探讨芬戈莫德相关性黄斑水肿（FAME）的临床特点、治疗及预后，为其合理管理提供参考。

通过检索 2010 年至 2021 年 11 月 31 日的中英文数据库，将 FAME 相关病例报告纳入汇总分析。

41 名患者的中位年龄为 50 岁（范围为 21、67 岁），其中 32 名是女性。FAME 发病的中位时间为 3 m（范围.03, 120），视力模糊（17 例）和视力下降（13 例）是最常见的主诉。FAME共涉及55眼，包括左眼（14例）、右眼（10例）、双眼（15例），其中46眼最佳矫正视力接近正常（20/ 12-20/60）和8只眼有中度至重度视力障碍（20/80-20/500）。23例眼底检查示黄斑水肿（11例）。39例患者的光学相干断层扫描（OCT）主要表现为中央凹周围囊肿（24例）、ME（23例）和中央凹增厚（19例）。18 例眼底荧光血管造影（FFA）显示血管渗漏（11 例）。

黄斑水肿是芬戈莫德的一种已知并发症。所有使用芬戈莫德的患者都需要定期进行眼科检查，尤其是那些有糖尿病和葡萄膜炎病史以及接受白内障手术的患者。