Back ground/aims To determine whether parapapillary choroidal microvasculature (PPCMv) density, measured by optical coherence tomography angiography, differed between acute primary angle-closure (APAC), primary open-angle glaucoma (POAG) and controls. Methods This is a prospective, cross-sectional, observational study. Data from 149 eyes from two academic referral centres were analysed. Automated PPCMv density was calculated in inner and outer annuli around the optic nerve region in addition to the peripapillary superficial vasculature, using customised software. A generalised estimating equation was used to compare vessel densities among groups, adjusted for confounders. Results Data from 40 eyes with APAC, 65 eyes with POAG and 44 eyes in healthy controls were gathered and analysed. Global radial peripapillary capillary densities were reduced in eyes with APAC and POAG compared with controls (p=0.027 and 0.136, respectively). Mean outer annular PPCMv density in the POAG group was lower vs the APAC group by 3.6% (95% CI 0.6% to 6.5%) (p=0.018) in the multivariable model adjusted for confounders. The mean difference in inner and outer superior PPCMv between the POAG and APAC groups was 5.9% and 4.4% (95% CI 1.9% to 9.9% and 1.0% to 7.7%, respectively; both p<0.010). Furthermore, POAG and APAC groups both had significantly lower PPCMv compared with controls (both, p<0.001). Conclusions While superficial peripapillary vessels were affected to similar degrees in POAG and APAC, PPCMv drop-out was greater with POAG versus APAC, suggesting that choroidal vessel density may be affected to a lesser extent following an acute increase in intraocular pressure before glaucoma develops. Data are available on reasonable request.

中文翻译：

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急性原发性闭角型和原发性开角型青光眼中乳头旁脉络膜微血管密度：光学相干断层扫描血管造影研究

背景/目的 确定通过光学相干断层扫描血管造影测量的乳头旁脉络膜微血管 (PPCMv) 密度在急性原发性闭角型 (APAC)、原发性开角型青光眼 (POAG) 和对照之间是否存在差异。方法 这是一项前瞻性、横断面、观察性研究。对来自两个学术转诊中心的 149 只眼睛的数据进行了分析。使用定制软件计算视神经区域周围的内环和外环以及视乳头周围浅表脉管系统的自动 PPCMv 密度。使用广义估计方程来比较各组之间的血管密度，并针对混杂因素进行调整。结果 收集并分析了 40 只 APAC 眼、65 只 POAG 眼和 44 只健康对照眼的数据。与对照组相比，APAC 和 POAG 眼的整体径向乳头周围毛细血管密度降低（分别为 p=0.027 和 0.136）。在针对混杂因素进行调整的多变量模型中，POAG 组的平均外环 PPCMv 密度比 APAC 组低 3.6%（95% CI 0.6% 至 6.5%）（p=0.018）。POAG 组和 APAC 组之间内、外上 PPCMv 的平均差异为 5.9% 和 4.4%（95% CI 分别为 1.9% 至 9.9% 和 1.0% 至 7.7%；均 p<0.010）。此外，与对照组相比，POAG 组和 APAC 组的 PPCMv 均显着降低（均 p<0.001）。结论 虽然 POAG 和 APAC 中视乳头周围浅血管受到的影响程度相似，但与 APAC 相比，POAG 中 PPCMv 脱落率更高，这表明青光眼发生前眼压急剧升高后脉络膜血管密度可能受到较小程度的影响。可根据合理要求提供数据。