Structural maintenance of chromosomes (SMC) complexes such as condensin regulate chromosome organization by extruding loops. A new study uses single-molecule imaging of condensin on supercoiled DNA to understand how condensins navigate the under- and overwound DNA states common throughout the genome.

中文翻译：

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卷入它：DNA 拓扑结构如何通过凝聚素驱动环挤出

染色体结构维护 (SMC) 复合物（例如凝聚素）通过挤压环来调节染色体组织。一项新研究使用超螺旋 DNA 上凝缩蛋白的单分子成像来了解凝缩蛋白如何在整个基因组中常见的缠绕不足和过度缠绕的 DNA 状态中导航。