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Association of PCOS with offspring morbidity: a longitudinal cohort study
Human Reproduction ( IF 6.1 ) Pub Date : 2022-07-13 , DOI: 10.1093/humrep/deac154 Shu Qin Wei 1, 2 , Marianne Bilodeau-Bertrand 2 , Nathalie Auger 2, 3, 4
Human Reproduction ( IF 6.1 ) Pub Date : 2022-07-13 , DOI: 10.1093/humrep/deac154 Shu Qin Wei 1, 2 , Marianne Bilodeau-Bertrand 2 , Nathalie Auger 2, 3, 4
Affiliation
STUDY QUESTION Do children whose mothers have polycystic ovary syndrome (PCOS) have an increased risk of morbidity? SUMMARY ANSWER Maternal PCOS is associated with an increased risk of infection, allergy and other childhood morbidity. WHAT IS KNOWN ALREADY PCOS is associated with higher rates of gestational diabetes, pre-eclampsia and preterm delivery, but the long-term impact on child health is poorly understood. STUDY DESIGN, SIZE, DURATION We conducted a retrospective longitudinal cohort study of 1 038 375 children in Quebec between 2006 and 2020. PARTICIPANTS/MATERIALS, SETTING, METHODS We included 7160 children whose mothers had PCOS and 1 031 215 unexposed children. Outcomes included child hospitalization for infectious, allergic, malignant and other diseases before 13 years of age. We estimated hazard ratios (HRs) and 95% CI for the association of PCOS with childhood morbidity in adjusted Cox proportional hazards regression models. MAIN RESULTS AND THE ROLE OF CHANCE Children exposed to PCOS were hospitalized at a rate of 68.9 (95% CI 66.2–71.8) per 1000 person-years, whereas unexposed children were hospitalized at a rate of 45.3 (95% CI 45.1–45.5) per 1000 person-years. Compared with no exposure, maternal PCOS was associated with 1.32 times the risk of any childhood hospitalization (95% CI 1.26–1.40), 1.31 times the risk of infectious disease hospitalization (95% CI 1.25–1.38) and 1.47 times the risk of allergy-related hospitalization (95% CI 1.31–1.66). Risk of hospitalization was also elevated for childhood metabolic (HR 1.59, 95% CI 1.16–2.18), gastrointestinal (HR 1.72, 95% CI 1.53–1.92), central nervous system (HR 1.74, 95% CI 1.46–2.07) and otologic disorders (HR 1.34, 95% CI 1.26–1.43). Subgroup analyses suggested that there was little difference in the association of PCOS with hospitalization among boys (HR 1.31, 95% CI 1.24–1.39) and girls (HR 1.34, 95% CI 1.26–1.43). LIMITATIONS, REASONS FOR CAUTION We analyzed severe childhood morbidity requiring hospitalization, not mild diseases treated in ambulatory clinics. We lacked data on ethnicity, education and physical activity, and cannot rule out residual confounding. WIDER IMPLICATIONS OF THE FINDINGS Our findings suggest that maternal PCOS is associated with an increased risk of childhood morbidity. STUDY FUNDING/COMPETING INTEREST(S) This study was supported by grant PJT-162300 from the Canadian Institutes of Health Research. N.A. acknowledges a career award from the Fonds de recherche du Québec-Santé (296785). The authors declare no competing interests. TRIAL REGISTRATION NUMBER N/A.
中文翻译:
PCOS 与后代发病率的关联:纵向队列研究
研究问题 母亲患有多囊卵巢综合症 (PCOS) 的孩子发病风险是否会增加?摘要答案 母亲多囊卵巢综合症与感染、过敏和其他儿童发病风险增加有关。已知的情况 多囊卵巢综合症与较高的妊娠期糖尿病、先兆子痫和早产发生率有关,但其对儿童健康的长期影响却知之甚少。研究设计、规模、持续时间 我们对 2006 年至 2020 年间魁北克省的 1 038 375 名儿童进行了一项回顾性纵向队列研究。参与者/材料、环境、方法 我们纳入了 7160 名母亲患有 PCOS 的儿童和 1 031 215 名未暴露的儿童。结果包括儿童在 13 岁之前因传染性、过敏性、恶性和其他疾病住院治疗。我们在调整后的 Cox 比例风险回归模型中估计了 PCOS 与儿童发病率关联的风险比 (HR) 和 95% CI。主要结果和机会的作用 接触 PCOS 的儿童住院率为每 1000 人年 68.9 例(95% CI 66.2–71.8),而未接触 PCOS 的儿童住院率为 45.3 例(95% CI 45.1–45.5)每1000人年。与未暴露相比,孕产妇多囊卵巢综合症与任何儿童住院风险分别为 1.32 倍(95% CI 1.26-1.40)、1.31 倍传染病住院风险(95% CI 1.25-1.38)以及 1.47 倍过敏风险相关住院治疗(95% CI 1.31–1.66)。儿童代谢疾病(HR 1.59,95% CI 1.16-2.18)、胃肠道疾病(HR 1.72,95% CI 1.53-1.92)、中枢神经系统疾病(HR 1.16)的住院风险也有所升高。74,95% CI 1.46–2.07)和耳科疾病(HR 1.34,95% CI 1.26–1.43)。亚组分析表明,男孩(HR 1.31,95% CI 1.24-1.39)和女孩(HR 1.34,95% CI 1.26-1.43)之间 PCOS 与住院的关联几乎没有差异。局限性和注意理由 我们分析了需要住院治疗的严重儿童发病率,而不是门诊诊所治疗的轻微疾病。我们缺乏有关种族、教育程度和身体活动的数据,因此不能排除残留的混杂因素。研究结果的更广泛意义 我们的研究结果表明,母亲多囊卵巢综合症与儿童发病风险增加有关。研究经费/竞争利益 这项研究得到了加拿大健康研究所 PJT-162300 的资助。不适用 承认 Québec-Santé 基金会颁发的职业奖 (296785)。作者声明没有竞争利益。试用注册号 不适用。
更新日期:2022-07-13
中文翻译:
PCOS 与后代发病率的关联:纵向队列研究
研究问题 母亲患有多囊卵巢综合症 (PCOS) 的孩子发病风险是否会增加?摘要答案 母亲多囊卵巢综合症与感染、过敏和其他儿童发病风险增加有关。已知的情况 多囊卵巢综合症与较高的妊娠期糖尿病、先兆子痫和早产发生率有关,但其对儿童健康的长期影响却知之甚少。研究设计、规模、持续时间 我们对 2006 年至 2020 年间魁北克省的 1 038 375 名儿童进行了一项回顾性纵向队列研究。参与者/材料、环境、方法 我们纳入了 7160 名母亲患有 PCOS 的儿童和 1 031 215 名未暴露的儿童。结果包括儿童在 13 岁之前因传染性、过敏性、恶性和其他疾病住院治疗。我们在调整后的 Cox 比例风险回归模型中估计了 PCOS 与儿童发病率关联的风险比 (HR) 和 95% CI。主要结果和机会的作用 接触 PCOS 的儿童住院率为每 1000 人年 68.9 例(95% CI 66.2–71.8),而未接触 PCOS 的儿童住院率为 45.3 例(95% CI 45.1–45.5)每1000人年。与未暴露相比,孕产妇多囊卵巢综合症与任何儿童住院风险分别为 1.32 倍(95% CI 1.26-1.40)、1.31 倍传染病住院风险(95% CI 1.25-1.38)以及 1.47 倍过敏风险相关住院治疗(95% CI 1.31–1.66)。儿童代谢疾病(HR 1.59,95% CI 1.16-2.18)、胃肠道疾病(HR 1.72,95% CI 1.53-1.92)、中枢神经系统疾病(HR 1.16)的住院风险也有所升高。74,95% CI 1.46–2.07)和耳科疾病(HR 1.34,95% CI 1.26–1.43)。亚组分析表明,男孩(HR 1.31,95% CI 1.24-1.39)和女孩(HR 1.34,95% CI 1.26-1.43)之间 PCOS 与住院的关联几乎没有差异。局限性和注意理由 我们分析了需要住院治疗的严重儿童发病率,而不是门诊诊所治疗的轻微疾病。我们缺乏有关种族、教育程度和身体活动的数据,因此不能排除残留的混杂因素。研究结果的更广泛意义 我们的研究结果表明,母亲多囊卵巢综合症与儿童发病风险增加有关。研究经费/竞争利益 这项研究得到了加拿大健康研究所 PJT-162300 的资助。不适用 承认 Québec-Santé 基金会颁发的职业奖 (296785)。作者声明没有竞争利益。试用注册号 不适用。