Tissue damage and persistent inflammation are distinctive features of antibiotic-resistant chronic infections. In this issue of Cell Host & Microbe, Tang et al. demonstrate that anti-folate antibiotics trigger the synthesis of a bacterial second messenger, which induces an exuberant immune response and establishes a paradigm for chronic infection.

中文翻译：

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抗生素治疗点燃持续的火焰

组织损伤和持续性炎症是耐抗生素慢性感染的显着特征。在本期Cell Host & Microbe中，Tang 等人。证明抗叶酸抗生素会触发细菌第二信使的合成，从而诱导旺盛的免疫反应并建立慢性感染的范例。