Type 1 CD8 T cells (Tc1s) have been implicated in liver injury in autoimmune hepatitis (AIH) through mechanisms that have so far been unclear. In this issue of Cell Host & Microbe, Pandey et al. show that the aryl hydrocarbon receptor ligand-producing pathobiont Lactobacillus reuteri induces Tc1-mediated AIH-like pathology in mice with Tet-methylcytosine-dioxygenase-2 deficiency.

中文翻译：

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罗伊氏乳杆菌加入肝脏自身免疫领域

通过迄今为止尚不清楚的机制，1 型 CD8 T 细胞 (Tc1s) 与自身免疫性肝炎 (AIH) 的肝损伤有关。在本期Cell Host & Microbe中，Pandey 等人。表明产生芳烃受体配体的病原体罗伊氏乳杆菌在 Tet-甲基胞嘧啶-双加氧酶 2 缺乏的小鼠中诱导 Tc1 介导的 AIH 样病理。