The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a phenotype that has changed fundamentally compared with preceding variants. Substantial antigenic change within the spike protein and a new endocytic entry mechanism underlie the immune evasion characteristics and a coincident decrease in the virulence of this variant.

中文翻译：

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Omicron：SARS-CoV-2 生物学的转变

与之前的变体相比，严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 的 Omicron 变体具有根本变化的表型。刺突蛋白内的大量抗原变化和新的内吞进入机制是免疫逃避特征和该变体毒力同时降低的基础。