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Optically Manipulated Neutrophils as Native Microcrafts In Vivo
ACS Central Science ( IF 18.2 ) Pub Date : 2022-07-13 , DOI: 10.1021/acscentsci.2c00468
Xiaoshuai Liu 1 , Qing Gao 1 , Shuai Wu 1 , Haifeng Qin 1 , Tiange Zhang 1 , Xianchuang Zheng 1 , Baojun Li 1
Affiliation  

As the first line of host defense against invading pathogens, neutrophils have an inherent phagocytosis capability for the elimination of foreign agents and target loading upon activation, as well as the ability to transmigrate across blood vessels to the infected tissue, making them natural candidates to execute various medical tasks in vivo. However, most of the existing neutrophil-based strategies rely on their spontaneous chemotactic motion, lacking in effective activation, rapid migration, and high navigation precision. Here, we report an optically manipulated neutrophil microcraft in vivo through the organic integration of endogenous neutrophils and scanning optical tweezers, functioning as a native biological material and wireless remote controller, respectively. The neutrophil microcrafts can be remotely activated by light and then navigated to the target position along a designated route, followed by the fulfillment of its task in vivo, such as active intercellular connection, targeted delivery of nanomedicine, and precise elimination of cell debris, free from the extra construction or modification of the native neutrophils. On the basis of the innate immunologic function of neutrophils and intelligent optical manipulation, the proposed neutrophil microcraft might provide new insight for the construction of native medical microdevices for drug delivery and precise treatment of inflammatory diseases.

中文翻译:

光学操作的中性粒细胞作为体内的原生微型工艺品

作为宿主抵御病原体入侵的第一道防线,中性粒细胞具有固有的吞噬能力,​​可消除外来因子并在激活时加载靶标,并具有跨血管迁移到受感染组织的能力,使其成为执行的天然候选者体内各种医疗任务。然而,现有的大多数基于中性粒细胞的策略依赖于它们的自发趋化运动,缺乏有效激活、快速迁移和高导航精度。在这里,我们报告了一种体内光学操纵的中性粒细胞显微技术通过内源性中性粒细胞和扫描光镊的有机结合,分别起到天然生物材料和无线遥控器的作用。中性粒细胞微型飞行器可以通过光远程激活,然后沿着指定路线导航到目标位置,然后在体内完成其任务,例如主动细胞间连接、纳米药物的靶向递送和细胞碎片的精确消除,无需额外构建或修饰天然中性粒细胞。基于中性粒细胞的先天免疫功能和智能光学操作,所提出的中性粒细胞显微技术可能为构建用于药物输送和炎症性疾病精准治疗的天然医疗微装置提供新的见解。
更新日期:2022-07-13
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