I propose an approach that expands philosophical views of scientific change, on the basis of an analysis of contemporary biomedical research and recent developments in the philosophy of scientific change. Focusing on the establishment of the exposome in epidemiology as a case study and the role of data as a context for contrasting views on change, I discuss change at conceptual, methodological, material, and social levels of biomedical epistemology. Available models of change provide key resources to discuss this type of change, but I present the need for an approach that models transfer, alignment, and influence as key processes of change. I develop this as a pragmatic approach to scientific change, where processes might change substantially depending on specific circumstances, thus contributing to and complementing the debate on a crucial epistemological issue.

在分析当代生物医学研究和科学变革哲学的最新发展的基础上，我提出了一种扩展科学变革哲学观点的方法。重点关注流行病学中暴露组的建立作为案例研究，以及数据作为对比变化观点的背景的作用，我讨论了生物医学认识论的概念、方法、材料和社会层面的变化。可用的变更模型为讨论此类变更提供了关键资源，但我提出需要一种方法，将转移、调整和影响建模为关键的变更过程。我将此发展为务实的科学变革的方法，其中过程可能会根据具体情况发生重大变化，从而有助于和补充关于关键认识论问题的辩论。