Objectives To evaluate nailfold videocapillaroscopy (NVC) as a useful tool for assessing the disease activity of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Methods This study enrolled 51 patients with AAV and 21 healthy controls. We scored NVC findings semi-quantitatively, and compared them between AAV patients and controls. We examined the association of NVC findings with disease activity indicators, histopathological findings of skin biopsies, and high-resolution computed tomography (HRCT) scores in AAV. Additionally, we repeatedly rated the NVC findings 3 months after immunosuppressive therapy. Results 70.6% (36/51) showed a microangiopathy pattern and 7.8% (4/51) showed a scleroderma pattern in AAV. The scores for microhemorrhage, capillary loss, neoangiogenesis, and tortuosity were significantly higher in the AAV group than in the control group. NVC abnormalities correlated with the severity of skin, lung, and kidney involvement. The scores of giant capillaries significantly correlated with the total BVAS and the chest BVAS; the scores of capillary loss correlated with the chest BVAS and the renal BVAS. The scores of microhemorrhage significantly correlated with perivascular inflammatory cell infiltrations in the upper dermis of the purpura and tended to correlate with the total ground-glass opacity and consolidation scores on HRCT. In addition, capillary loss scores had a significant positive correlation with serum creatinine levels. Additionally, the microhemorrhage scores significantly reduced after 3 months of immunosuppressive therapy. Conclusion In AAV patients, NVC abnormalities are significantly associated with disease severity. This result suggests that NVC is a useful tool for assessing the disease activity and treatment response in AAV.

中文翻译：

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检查 ANCA 相关性血管炎的甲襞视频毛细血管镜检查结果

目的 评估甲襞视频毛细血管镜检查 (NVC) 作为评估抗中性粒细胞胞质抗体 (ANCA) 相关血管炎 (AAV) 疾病活动性的有用工具。方法 本研究纳入了 51 名 AAV 患者和 21 名健康对照者。我们对 NVC 结果进行了半定量评分，并在 AAV 患者和对照组之间进行了比较。我们检查了 NVC 结果与疾病活动指标、皮肤活检组织病理学结果以及 AAV 高分辨率计算机断层扫描 (HRCT) 评分之间的关​​联。此外，我们在免疫抑制治疗后 3 个月反复评估 NVC 结果。结果 70.6% (36/51) 显示微血管病模式，7.8% (4/51) 显示 AAV 硬皮病模式。微出血、毛细血管丢失、新血管生成的评分，AAV 组的曲折度明显高于对照组。NVC 异常与皮肤、肺和肾脏受累的严重程度相关。巨毛细血管评分与总BVAS和胸部BVAS显着相关；毛细血管丢失评分与胸部 BVAS 和肾脏 BVAS 相关。微出血评分与紫癜真皮上层血管周围炎性细胞浸润显着相关，并倾向于与 HRCT 上的总磨玻璃混浊和实变评分相关。此外，毛细血管丢失评分与血清肌酐水平呈显着正相关。此外，免疫抑制治疗 3 个月后，微出血评分显着降低。结论 在 AAV 患者中，NVC 异常与疾病严重程度显着相关。这一结果表明 NVC 是评估 AAV 疾病活动和治疗反应的有用工具。