This review explores contributions in asymmetric organocatalysis from the patent literature since 2018, including reactions catalyzed by Cinchona alkaloids as free base and quaternary salts, phosphonium salts, proline-derived catalysts, and chiral phosphoric acids. Examples of processes employing asymmetric organocatalysis for the industrial preparation of pharmaceutical intermediates are highlighted.

中文翻译：

---

近期专利文献亮点：聚焦不对称有机催化

本综述探讨了自 2018 年以来专利文献对不对称有机催化的贡献，包括金鸡纳生物碱作为游离碱和季盐、鏻盐、脯氨酸衍生催化剂和手性磷酸催化的反应。重点介绍了使用不对称有机催化来工业制备药物中间体的工艺实例。