Comparative analytical performance of multiple plasma Aβ42 and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity,Alzheimer's & Dementia

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Comparative analytical performance of multiple plasma Aβ42 and Aβ40 assays and their ability to predict positron emission tomography amyloid positivity
Alzheimer's & Dementia ( IF 14.0 ) Pub Date : 2022-07-12 , DOI: 10.1002/alz.12697
Stephen Zicha ₁ , Randall J Bateman ₂ , Leslie M Shaw ₃ , Henrik Zetterberg _{4,

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7} , Anthony W Bannon ₈ , Wesley A Horton ₉ , Mike Baratta ₁ , Hartmuth C Kolb ₁₀ , Iwona Dobler ₁ , Yulia Mordashova ₁₁ , Ziad S Saad ₁₀ , David L Raunig ₁ , Emmanouil Manos Spanakis ₁₁ , Yan Li ₂ , Suzanne E Schindler ₂ , Kyle Ferber ₁₂ , Carrie E Rubel ₁₂ , Robert L Martone ₁₂ , Christopher J Weber ₁₃ , Rebecca M Edelmayer ₁₃ , Emily A Meyers ₁₃ , James G Bollinger ₂ , Erin G Rosenbaugh ₉ , William Z Potter ₁₄ , ,

Affiliation

Takeda, Pharmaceutical Company Ltd., Cambridge, Massachusetts, USA.
Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, The Sahlgrenska Academy at University of Gothenburg, Mölndal, Sweden.
Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
UK Dementia Research Institute Fluid Biomarkers Laboratory, UK DRI at UCL, London, UK.
Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London, UK.
AbbVie, North Chicago, Illinois, USA.
The Foundation for the National Institutes of Health, North Bethesda, Maryland, USA.
Neuroscience Biomarkers, Janssen Research and Development LLC, La Jolla, California, USA.
AbbVie Deutschland GmbH & Co KG, Ludwigshafen, Germany.
Biogen, Cambridge, Massachusetts, USA.
Alzheimer's Association, Chicago, Illinois, USA.
Highly qualified expert.

This report details the approach taken to providing a dataset allowing for analyses on the performance of recently developed assays of amyloid beta (Aβ) peptides in plasma and the extent to which they improve the prediction of amyloid positivity.

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