Phytochemistry Letters ( IF 1.7 ) Pub Date : 2022-07-12 , DOI: 10.1016/j.phytol.2022.06.012 Yan-Jie Wang , Jun Yang , Xiao-Nian Li , Hua Bai , Ji-Feng Luo , Zhao-Rong He , Yue-Hu Wang
The chemical structures of nine cucurbitane-type triterpenoids from the branches and leaves of Elaeocarpus sylvestris (Elaeocarpaceae), including undescribed 29-hydroxymogroside I E2, epimogroside I E2, epimogroside I E1, 24-oxomogroside I E1, and 11-O-acetylmogroside I E1, were determined using mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy. The absolute configuration of 29-hydroxymogroside I E2 was confirmed by performing an X-ray diffraction analysis. Cucurbitacin D and 11-O-acetylmogroside I E1 showed cytotoxicity toward human leukemia HL-60, human lung adenocarcinoma A549, human hepatoma SMMC-7721, human breast cancer MCF-7, and human colon cancer SW480 cell lines. The presence of a 11-O-acetyl group might increase the cytotoxicity of this type of triterpenoids.
中文翻译:
樟子松枝叶中的葫芦烷型三萜类化合物
樟子松(Elaeocarpaceae)枝叶九种葫芦烷型三萜的化学结构,包括未描述的 29-羟基罗汉果苷 IE 2 、表罗汉果苷 IE 2、表罗汉果苷 IE 1、24-氧代罗汉果苷 IE 1和 11 - O-乙酰罗汉果苷 IE如图1所示,使用质谱(MS)和核磁共振(NMR)光谱测定。29-羟基罗汉果苷IE 2的绝对构型通过进行X射线衍射分析来确认。葫芦素 D 和 11 - O-乙酰罗汉果苷 IE 1显示对人白血病 HL-60、人肺腺癌 A549、人肝癌 SMMC-7721、人乳腺癌 MCF-7 和人结肠癌 SW480 细胞系的细胞毒性。11- O-乙酰基的存在可能会增加此类三萜类化合物的细胞毒性。