Background: Oxidative stress status may affect bone metabolism and regeneration. However, few studies reported whether oxidative stress could impact the outcomes of hip fractures. This study aimed to explore if superoxide dismutase and glutathione reductase, the critical antioxidant enzymes, correlated with the prognosis of hip fractures.
Methods: Patients with hip fractures were extracted from our database, and those who met the inclusion criteria were analyzed. Propensity score matching was used to reduce the influence of confounding factors, and ROC curves based on matched populations were created to determine the optimal cutoff points of SOD and GR. Then, outcomes between SOD or GR and outcomes of hip fractures were compared.
Results: Out of 301 patients enrolled in this study, 50 patients died within one year. After a 1:1 PSM, the patients with less than 1-year survival had significantly lower SOD (p = 0.026) and GR (p = 0.021) than those who were still alive at one year. Logistics analysis showed that low SOD and low GR may be independent risk factors for 6-month survival, 1-year survival, 6-month free walking ability, and 1-year free walking ability.
Conclusion: SOD and GR may be the independent risk factors for survival and walking abilities of hip fractures.



中文翻译：

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超氧化物歧化酶和谷胱甘肽还原酶作为氧化应激水平的指标可能与老年髋部骨折的生存和行走能力有关：倾向评分匹配研究

背景：氧化应激状态可能影响骨代谢和再生。然而，很少有研究报告氧化应激是否会影响髋部骨折的结果。本研究旨在探讨超氧化物歧化酶和谷胱甘肽还原酶（关键的抗氧化酶）是否与髋部骨折的预后相关。
方法：从我们的数据库中提取髋部骨折患者，对符合纳入标准的患者进行分析。采用倾向得分匹配减少混杂因素的影响，建立基于匹配人群的ROC曲线以确定SOD和GR的最佳截断点。然后，比较了 SOD 或 GR 之间的结果与髋部骨折的结果。
结果：在参加这项研究的 301 名患者中，有 50 名患者在一年内死亡。在 1:1 PSM 后，存活不到 1 年的患者的 SOD (p = 0.026) 和 GR (p = 0.021) 明显低于存活一年的患者。后勤分析表明，低SOD和低GR可能是6个月存活率、1年存活率、6个月自由步行能力和1年自由步行能力的独立危险因素。
结论： SOD和GR可能是髋部骨折生存和行走能力的独立危险因素。