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Next-generation pathology practices with mass spectrometry imaging
Mass Spectrometry Reviews ( IF 6.6 ) Pub Date : 2022-07-11 , DOI: 10.1002/mas.21795
Hsin-Hsiang Chung, Penghsuan Huang, Chih-Lin Chen, Chuping Lee, Cheng-Chih Hsu

Mass spectrometry imaging (MSI) is a powerful technique that reveals the spatial distribution of various molecules in biological samples, and it is widely used in pathology-related research. In this review, we summarize common MSI techniques, including matrix-assisted laser desorption/ionization and desorption electrospray ionization MSI, and their applications in pathological research, including disease diagnosis, microbiology, and drug discovery. We also describe the improvements of MSI, focusing on the accumulation of imaging data sets, expansion of chemical coverage, and identification of biological significant molecules, that have prompted the evolution of MSI to meet the requirements of pathology practices. Overall, this review details the applications and improvements of MSI techniques, demonstrating the potential of integrating MSI techniques into next-generation pathology practices.

中文翻译:

新一代病理学实践与质谱成像

质谱成像(MSI)是一种揭示生物样本中各种分子空间分布的强大技术,广泛应用于病理学相关研究。在这篇综述中,我们总结了常见的 MSI 技术,包括基质辅助激光解吸/电离和解吸电喷雾电离 MSI,及其在病理研究(包括疾病诊断、微生物学和药物发现)中的应用。我们还描述了 MSI 的改进,重点是成像数据集的积累、化学覆盖范围的扩大以及生物重要分子的识别,这些改进促使 MSI 的发展以满足病理学实践的要求。总的来说,这篇综述详细介绍了 MSI 技术的应用和改进,展示了将 MSI 技术整合到下一代病理学实践中的潜力。
更新日期:2022-07-11
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