Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age.,Journal of the Pediatric Infectious Diseases Society

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Stool Toxin Concentration Does Not Distinguish Clostridioides difficile Infection from Colonization in Children Less Than 3 Years of Age.
Journal of the Pediatric Infectious Diseases Society ( IF 3.2 ) Pub Date : 2022-10-25 , DOI: 10.1093/jpids/piac059
Thomas J Sandora ₁ , David N Williams ₂ , Kaitlyn Daugherty ₃ , Christine Geer _{2,

3} , Christine Cuddemi ₃ , Larry K Kociolek ₄ , Xinhua Chen ₃ , Hua Xu ₃ , Timothy J Savage ₁ , Alice Banz ₅ , Kevin W Garey ₆ , Anne J Gonzales-Luna ₆ , Ciarán P Kelly ₃ , Nira R Pollock _{7,

8}

Affiliation

Division of Infectious Diseases, Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Institutional Centers for Clinical and Translational Research, Boston Children's Hospital, Boston, Massachusetts, USA.
Division of Gastroenterology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Division of Infectious Diseases, Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
bioMerieux, Marcy L'Etoile, France.
Department of Pharmacy Practice and Translational Research, University of Houston College of Pharmacy, Houston, Texas, USA.
Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Division of Infectious Diseases, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.

In a prospective cohort study, stools from children <3 years with and without diarrhea who were Clostridioides difficile nucleic acid amplification test-positive underwent ultrasensitive and quantitative toxin measurement. Among 37 cases and 46 controls, toxin concentration distributions overlapped substantially. Toxin concentration alone does not distinguish C. difficile infection from colonization in young children.

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