In this issue of Cell Stem Cell, Jin et al. report that human Down syndrome microglia exhibit enhanced synaptic engulfment and accelerated tau-induced cellular senescence in human-mouse chimeric brains. They show that inhibiting interferon signaling rescues both developmental and tau-associated phenotypes, rendering it a potential therapeutic target for Down syndrome.

中文翻译：

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人类唐氏综合症小胶质细胞即将迎来突触盛宴

在本期Cell Stem Cell中，Jin 等人。报告说，人类唐氏综合症小胶质细胞在人鼠嵌合脑中表现出增强的突触吞噬和加速 tau 诱导的细胞衰老。他们表明，抑制干扰素信号可以挽救发育和 tau 相关表型，使其成为唐氏综合症的潜在治疗靶点。