The mammalian embryo exhibits a remarkable plasticity that allows it to correct for the presence of aberrant cells, adjust its growth so that its size is in accordance with its developmental stage, or integrate cells of another species to form fully functional organs. Here, we will discuss the contribution that cell competition, a quality control that eliminates viable cells that are less fit than their neighbors, makes to this plasticity. We will do this by reviewing the roles that cell competition plays in the early mammalian embryo and how they contribute to ensure normal development of the embryo.

中文翻译：

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细胞竞争和早期哺乳动物发育的调节性质

哺乳动物胚胎表现出非凡的可塑性，使其能够纠正异常细胞的存在，调整其生长以使其大小与其发育阶段一致，或整合其他物种的细胞以形成功能齐全的器官。在这里，我们将讨论细胞竞争对这种可塑性的贡献，细胞竞争是一种质量控制，可以消除比邻居更不适合的活细胞。我们将通过回顾细胞竞争在早期哺乳动物胚胎中所起的作用以及它们如何有助于确保胚胎的正常发育来做到这一点。