Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson’s disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS). While beta fluctuations in PD patients are well characterized on shorter timescales, it is not known how beta activity evolves around the diurnal cycle, outside a clinical setting. Here, we obtained chronic recordings (34 ± 13 days) of subthalamic beta power in PD patients implanted with the Percept DBS device during high-frequency DBS and analysed their diurnal properties as well as sensitivity to artifacts. Time of day explained 41 ± 9% of the variance in beta power (p < 0.001 in all patients), with increased beta during the day and reduced beta at night. Certain movements affected LFP quality, which may have contributed to diurnal patterns in some patients. Future DBS algorithms may benefit from taking such diurnal and artifactual fluctuations in beta power into account.

丘脑底局部场电位 (LFP) 中的 β 波段活动与帕金森病 (PD) 症状严重程度相关，并且是深部脑刺激 (DBS) 的治疗目标。虽然 PD 患者的 β 波动在较短的时间尺度上得到了很好的表征，但在临床环境之外，β 活动如何围绕昼夜周期演变尚不清楚。在这里，我们获得了在高频 DBS 期间植入 Percept DBS 设备的 PD 患者的丘脑底 β 功率的慢性记录（34 ± 13 天），并分析了它们的昼夜特性以及对伪影的敏感性。一天中的时间解释了 41 ± 9% 的 beta 功率 ( p < 0.001（所有患者），白天 β 升高，夜间 β 降低。某些运动会影响 LFP 质量，这可能导致某些患者的昼夜模式。未来的 DBS 算法可能会受益于考虑到 beta 功率的这种昼夜和人为波动。