PURPOSE

To investigate the association between intermittent fasting and age-related macular degeneration (AMD) in the general older adult population.

DESIGN

A cross-sectional study using a population-based, government-led survey data, Korean National Health and Nutrition Examination Survey (KNHANES).

METHODS

A total of 4504 individuals aged ≥55 years with comprehensive data including meal frequency and fundus photography were selected using the KNHANES 2015-2018 database. Participants were divided into 2 groups based on breakfast frequency per week; intermittent fasting (nearly 0 time/week) and nonfasting (5-7 times/week) groups. Multiple logistic regression analysis was performed to determine the risk factors for AMD identified by fundus photography.

RESULTS

AMD was identified in 25.1% of total participants. The intermittent fasting group had a decreased risk of AMD compared with the nonfasting group (adjusted odds ratio [aOR] 0.413, 95% CI 0.203-0.841), especially in individuals with a younger age (<70 years, aOR 0.357, 95% CI 0.153-0.833), obesity (aOR 0.663, 95% CI 0.424-1.037), and urban residence (aOR 0.437, 95% CI 0.248-0.769). Increased age (aOR 1.058, 95% CI 1.041-1.076) and serum high-density lipoprotein levels (aOR 1.011, 95% CI 1.002-1.021) were also independent risk factors for AMD.

CONCLUSIONS

Using the population-based survey data, we demonstrated that intermittent fasting by skipping breakfast was significantly associated with a reduced risk of AMD in a representative older adult population, especially in individuals with age <70 years, obesity, and urban residence.

中文翻译：

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间歇性禁食可降低年龄相关性黄斑变性的风险

目的

调查一般老年人群中间歇性禁食与年龄相关性黄斑变性 (AMD) 之间的关联。

设计

一项横断面研究，使用基于人口、政府主导的调查数据——韩国国家健康和营养检查调查 (KNHANES)。

方法

利用KNHANES 2015-2018数据库选取了4504名年龄≥55岁、具有进餐频率、眼底照相等综合数据的个体。根据每周早餐频率，参与者被分为 2 组；间歇性禁食（近 0 次/周）组和非禁食（5-7 次/周）组。进行多重逻辑回归分析以确定通过眼底照相确定的 AMD 的危险因素。

结果

总参与者中 25.1% 的人发现了 AMD。与非禁食组相比，间歇性禁食组的 AMD 风险降低（调整后比值比 [aOR] 0.413，95% CI 0.203-0.841），尤其是年龄较小的个体（<70 岁，aOR 0.357，95% CI 0.153-0.833）、肥胖（aOR 0.663，95% CI 0.424-1.037）和城市居住（aOR 0.437，95% CI 0.248-0.769）。年龄增加（aOR 1.058，95% CI 1.041-1.076）和血清高密度脂蛋白水平（aOR 1.011，95% CI 1.002-1.021）也是AMD的独立危险因素。

结论

使用基于人群的调查数据，我们证明，在有代表性的老年人群中，通过不吃早餐进行间歇性禁食与 AMD 风险降低显着相关，特别是对于年龄 <70 岁、肥胖和居住在城市的个体。