ABSTRACT

Matrix solid phase dispersion (MSPD) is a rapid and flexible sample pretreatment method that accomplishes sample disruption, extraction, filtering and purification in one step and is especially suitable for solid, semisolid and viscous samples. More than 30 years have elapsed since it was first proposed, and there are many published reviews. However, there is no review on the use of MSPD to extract active compounds from natural products. In this review, the latest developments from 2015–2021 in MSPD microextraction techniques, including sorbents, elution solvents and assisted MSPD extraction, along with their applications in natural products, are systematically discussed and classified according to the structure of the active constituents, which mainly refer to phenolic acids, flavonoids, alkaloids, anthraquinones and terpenes.

摘要

基质固相分散（MSPD）是一种快速、灵活的样品前处理方法，可一步完成样品的破碎、萃取、过滤和纯化，特别适用于固体、半固体和粘稠样品。自首次提出以来已经过去了 30 多年，并且已经发表了许多评论。然而，目前还没有关于使用MSPD从天然产物中提取活性化合物的综述。本文系统地讨论了2015-2021年MSPD微萃取技术的最新进展，包括吸附剂、洗脱溶剂和辅助MSPD萃取，以及它们在天然产物中的应用，并根据活性成分的结构进行分类，主要包括指酚酸类、黄酮类、生物碱类、蒽醌类和萜烯类。