Contribution of MicroRNA-27b-3p to Synovial Fibrotic Responses in Knee Osteoarthritis,Arthritis & Rheumatology

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Contribution of MicroRNA-27b-3p to Synovial Fibrotic Responses in Knee Osteoarthritis
Arthritis & Rheumatology ( IF 13.3 ) Pub Date : 2022-07-06 , DOI: 10.1002/art.42285
Ghazaleh Tavallaee ₁ , Starlee Lively ₂ , Jason S Rockel ₂ , Shabana Amanda Ali ₃ , Michelle Im ₄ , Clementine Sarda ₂ , Greniqueca M Mitchell ₂ , Evgeny Rossomacha ₂ , Sayaka Nakamura ₂ , Pratibha Potla ₂ , Sarah Gabrial ₂ , John Matelski ₂ , Anusha Ratneswaran ₂ , Kim Perry ₂ , Boris Hinz ₅ , Rajiv Gandhi ₆ , Igor Jurisica ₇ , Mohit Kapoor ₈

Affiliation

Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, Krembil Research Institute, University Health Network, and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.
Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, and Krembil Research Institute, University Health Network, Toronto, Ontario, Canada.
Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, Krembil Research Institute, University Health Network, Toronto, Ontario, Canada, and Bone & Joint Center, Department of Orthopaedic Surgery, Henry Ford Health System, Detroit, Michigan.
Faculty of Dentistry, University of Toronto, Toronto, Ontario, Canada.
Faculty of Dentistry, University of Toronto, and Laboratory of Tissue Repair and Regeneration, Keenan Research Centre for Biomedical Science of the St. Michael's Hospital, Toronto, Ontario, Canada.
Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, Krembil Research Institute, University Health Network, and Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Ontario, Canada.
Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, Krembil Research Institute, University Health Network, Toronto, Departments of Medical Biophysics and Computer Science, University of Toronto, Toronto, Ontario, Canada, and Institute of Neuroimmunology, Slovak Academy of Sciences, Bratislava, Slovakia.
Osteoarthritis Research Program, Division of Orthopaedics, Schroeder Arthritis Institute, University Health Network, Krembil Research Institute, University Health Network, Department of Laboratory Medicine and Pathobiology, University of Toronto, and Division of Orthopaedic Surgery, Department of Surgery, University of Toronto, Toronto, Ontario, Canada.

Synovial fibrosis contributes to osteoarthritis (OA) pathology, but the underlying mechanisms remain unknown. We have observed increased microRNA-27b-3p (miR-27b-3p) levels in synovial fluid of patients with late-stage radiographic knee OA. Here, we investigated the contribution of miR-27b-3p to synovial fibrosis in patients with severe knee OA and in a mouse model of knee OA.

中文翻译：

MicroRNA-27b-3p 对膝关节骨性关节炎滑膜纤维化反应的贡献

滑膜纤维化导致骨关节炎 (OA) 病理，但其潜在机制仍然未知。我们观察到晚期膝关节 OA 患者滑液中 microRNA-27b-3p (miR-27b-3p) 水平升高。在这里，我们研究了 miR-27b-3p 对严重膝关节 OA 患者和膝关节 OA 小鼠模型滑膜纤维化的影响。

更新日期：2022-07-06

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