Itaconic acid, a Krebs cycle–derived immunometabolite, is synthesized by myeloid cells in response to danger signals to control inflammasome activation, type I interferon (IFN) responses, and oxidative stress. As these pathways are dysregulated in systemic lupus erythematosus (SLE), we investigated the role of an itaconic acid derivative in the treatment of established murine lupus.

中文翻译：

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衣康酸途径的调节减弱小鼠狼疮

衣康酸是一种克雷布斯循环衍生的免疫代谢物，由骨髓细胞合成以响应危险信号以控制炎性体激活、I 型干扰素 (IFN) 反应和氧化应激。由于这些途径在系统性红斑狼疮 (SLE) 中失调，我们研究了衣康酸衍生物在治疗已确诊的小鼠狼疮中的作用。