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Prevalence and Predictors of Potentially Inappropriate Medications Among Patients Aged ≥65 Years on Hospital Admissions in Kuwait
Clinical Interventions in Aging ( IF 3.6 ) Pub Date : 2022-07-06 , DOI: 10.2147/cia.s328693
Hesah Alshammari 1 , Eman Al-Saeed 1 , Zamzam Ahmed 1 , Zoe Aslanpour 1
Affiliation  

Background: Potentially inappropriate medications are major health concerns for patients aged ≥ 65 years. To investigate the prevalence of potentially inappropriate medications, Beer’s criteria can be used. We estimated the prevalence of potentially inappropriate medications prescription among patients aged ≥ 65 years admitted to Kuwait’s largest hospital and identified the predictors of prescribing a potentially inappropriate medication.
Methods: A cross-sectional study was conducted retrospectively using inpatient records from the medical department at the Hospital in Kuwait from 1 January 2019 to 31 December 2019. The latest version of Beer’s criteria was used to identify potentially inappropriate medications in patients’ medical records. Data were analyzed descriptively to estimate the prevalence of potentially inappropriate medications and to describe participant characteristics. The predictors of potentially inappropriate medications prescribing were determined using binary logistic regression.
Results: A total of 423 medical records of patients were collected. The mean age of the patients admitted was 76 ± 7 years, and 222 of them (52.5%) were women. Upon hospital admission, potentially inappropriate medication was prevalent in 58.4% of patients. The most prevalent potentially inappropriate medications identified were proton pump inhibitors (27.3%), diuretics (21.5%), antipsychotic agents (9%), selective serotonin reuptake inhibitors (5%), and methyldopa (4%). Polypharmacy, Alzheimer’s disease, depression, irritable bowel syndrome, hypothyroidism, chronic kidney disease were predictors of potentially inappropriate medications prescription.
Conclusion: A high prevalence of potentially inappropriate medication prescription was observed among patients aged ≥ 65 years admitted to a hospital in Kuwait. The most likely predictor of potentially inappropriate medication prescription was polypharmacy.



中文翻译:

科威特 65 岁以上住院患者中潜在不适当药物的流行率和预测因素

背景:对于 65 岁以上的患者来说,可能不适当的药物是主要的健康问题。为了调查潜在不适当药物的流行率,可以使用 Beer 标准。我们估计了科威特最大医院收治的 65 岁以上患者中潜在不适当药物处方的发生率,并确定了开具潜在不适当药物处方的预测因素。
方法:使用 2019 年 1 月 1 日至 2019 年 12 月 31 日科威特医院医疗部门的住院病历,回顾性地进行了一项横断面研究。最新版本的 Beer 标准用于识别患者病历中可能存在的不适当药物。对数据进行描述性分析,以估计潜在不适当药物的发生率并描述参与者特征。使用二元逻辑回归确定潜在不适当药物处方的预测因子。
结果:共收集患者病历423份。入院患者的平均年龄为 76 ± 7 岁,其中 222 人(52.5%)为女性。入院时,58.4% 的患者普遍存在可能不适当的药物治疗。最常见的潜在不当药物是质子泵抑制剂(27.3%)、利尿剂(21.5%)、抗精神病药(9%)、选择性5-羟色胺再摄取抑制剂(5%)和甲基多巴(4%)。多种药物、阿尔茨海默病、抑郁症、肠易激综合征、甲状腺功能减退、慢性肾病是潜在不适当药物处方的预测因素。
结论:在科威特一家医院收治的 65 岁以上的患者中,观察到潜在不适当的药物处方发生率很高。潜在不适当药物处方的最可能预测因素是多种药物。

更新日期:2022-07-06
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