Burn infection delays wound healing and increases the burn patient mortality. Consequently, a new dressing with antibacterial and anti-inflammatory dual properties is urgently required for wound healing. In this study, we propose a combination of methacrylate gelatin (GelMA) hydrogel system with silver nanoparticles embed in γ-cyclodextrin metal–organic frameworks (Ag@MOF) and hyaluronic acid-epigallocatechin gallate (HA-E) for the burn wound infection treatment. Ag@MOF is used as an antibacterial agent and epigallocatechin gallate (EGCG) has exhibited biological properties of anti-inflammation and antibacterial. The GelMA/HA-E/Ag@MOF hydrogel enjoys suitable physical properties and sustained release of Ag⁺. Meanwhile, the hydrogel has excellent biocompatibility and could promote macrophage polarization from M1 to M2. In vivo wound healing evaluations further demonstrate that the GelMA/HA-E/Ag@MOF hydrogel reduces the number of the bacterium efficiently, accelerates wound healing, promotes early angiogenesis, and regulates immune reaction. A further evaluation indicates that the noncanonical Wnt signal pathway is significantly activated in the GelMA/HA-E/Ag@MOF hydrogel treated group. In conclusion, the GelMA/HA-E/Ag@MOF hydrogel could serve as a promising multifunctional dressing for the burn wound healing.

中文翻译：

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具有抗菌和抗炎双重特性的生物功能水凝胶可对抗烧伤创面感染

烧伤感染会延迟伤口愈合并增加烧伤患者死亡率。因此，伤口愈合迫切需要一种具有抗菌和抗炎双重特性的新型敷料。在这项研究中，我们提出了将甲基丙烯酸酯明胶 (GelMA) 水凝胶系统与嵌入 γ-环糊精金属有机框架 (Ag@MOF) 和透明质酸-表没食子儿茶素没食子酸酯 (HA-E) 中的银纳米粒子组合用于烧伤创面感染治疗. Ag@MOF 用作抗菌剂，表没食子儿茶素没食子酸酯 (EGCG) 具有抗炎和抗菌的生物学特性。GelMA/HA-E/Ag@MOF 水凝胶具有合适的物理性能和 Ag ^{+的持续释放}. 同时，水凝胶具有良好的生物相容性，可以促进巨噬细胞从M1极化到M2极化。体内伤口愈合评估进一步表明，GelMA/HA-E/Ag@MOF水凝胶可有效减少细菌数量，加速伤口愈合，促进早期血管生成，调节免疫反应。进一步评估表明，非经典 Wnt 信号通路在 GelMA/HA-E/Ag@MOF 水凝胶处理组中被显着激活。总之，GelMA/HA-E/Ag@MOF 水凝胶可以作为烧伤创面愈合的一种很有前途的多功能敷料。