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A neuroimmunometabolic view on the cephalic phase of insulin release
Cell Metabolism ( IF 29.0 ) Pub Date : 2022-07-05 , DOI: 10.1016/j.cmet.2022.06.005
Gitalee Sarker 1 , Ana I Domingos 1
Affiliation  

The cephalic phase of insulin secretion (CPIS) plays a crucial role in glucose homeostasis. However, the neural basis of CPIS and its overall relevance to metabolic health are poorly understood. Here, we preview the findings of Wiedemann et al. (2022) that address the role of IL-1β in the integration of neuro-mediated insulin release following cephalic stimulation and CPIS dysregulation in obesity.



中文翻译:

关于胰岛素释放头期的神经免疫代谢观点

胰岛素分泌的头期(CPIS)在葡萄糖稳态中起着至关重要的作用。然而,人们对 CPIS 的神经基础及其与代谢健康的整体相关性知之甚少。在这里,我们预览了 Wiedemann 等人的研究结果。(2022 年)解决了 IL-1β 在头部刺激后神经介导的胰岛素释放整合和肥胖中 CPIS 失调中的作用。

更新日期:2022-07-05
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