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Gut associated metabolites and their roles in Clostridioides difficile pathogenesis
Gut Microbes ( IF 12.2 ) Pub Date : 2022-07-04 , DOI: 10.1080/19490976.2022.2094672
Andrea Martinez Aguirre 1 , Joseph A Sorg 1
Affiliation  

ABSTRACT

The nosocomial pathogen Clostridioides difficile is a burden to the healthcare system. Gut microbiome disruption, most commonly by broad-spectrum antibiotic treatment, is well established to generate a state that is susceptible to CDI. A variety of metabolites produced by the host and/or gut microbiota have been shown to interact with C. difficile. Certain bile acids promote/inhibit germination while other cholesterol-derived compounds and amino acids used in the Stickland metabolic pathway affect growth and CDI colonization. Short chain fatty acids maintain intestinal barrier integrity and a myriad of other metabolic compounds are used as nutritional sources or used by C. difficile to inhibit or outcompete other bacteria in the gut. As the move toward non-antibiotic CDI treatment takes place, a deeper understanding of interactions between C. difficile and the host’s gut microbiome and metabolites becomes more relevant.



中文翻译:

肠道相关代谢物及其在艰难梭菌发病机制中的作用

摘要

医院病原体艰难梭菌是医疗保健系统的负担。肠道微生物组的破坏,最常见的是广谱抗生素治疗,已经很好地产生了对 CDI 敏感的状态。宿主和/或肠道微生物群产生的多种代谢物已被证明与艰难梭菌相互作用。某些胆汁酸促进/抑制萌发,而 Stickland 代谢途径中使用的其他胆固醇衍生化合物和氨基酸影响生长和 CDI 定植。短链脂肪酸维持肠道屏障的完整性,许多其他代谢化合物被用作营养来源或被艰难梭菌使用抑制或胜过肠道中的其他细菌。随着向非抗生素 CDI 治疗的转变,对艰难梭菌与宿主肠道微生物组和代谢物之间相互作用的更深入了解变得更加相关。

更新日期:2022-07-05
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