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VEGF and eNOS variants may influence intervertebral disc degeneration
Nucleosides, Nucleotides & Nucleic Acids ( IF 1.3 ) Pub Date : 2022-07-05 , DOI: 10.1080/15257770.2022.2093363
Hasan Emre Aydin 1 , Serbulent Yigit 2 , Ismail Kaya 3 , Ercan Tural 4 , Sadegul Tuncer 5 , Ayse Feyda Nursal 6
Affiliation  

Abstract

Background: Intervertebral disc degeneration (IDD) is a common and complex condition. Vascular endothelial growth factor (VEGF) is one of the key regulators of angiogenesis and vascular permeability. Nitric oxide (NO) plays a role in various physiological events. The endothelial nitric oxide synthase (eNOS) that catalyses NO generation are crucial for the regulation of NO level. This study aimed to evaluate the association between VEGF/ eNOS gene variants with IDD. Materials and Methods: Two hundred ninety-one subjects (111 IDD patients and 180 controls) were included in the present case-control study. VEGF −2549 insertion/deletion (I/D) and eNOS VNTR variants were analysed by PCR method. The results of this analysis were evaluated for statistical significance. Results: There were no statistically significant differences in genotype and allele distribution of VEGF −2549 I/D/ eNOS VNTR variants between IDD patients and control subjects. We then evaluated the association between the allele frequencies of these variants and clinical features of IDD. Lumber IDD was more common in patients carrying VEGF I/D variant D allele (p < 0.001). Also, patients with lumbar disc herniation, cervical disc herniation, lumbar stenosis, and lumbar IDD had more 4 b allele (p = 0.005, p < 0.001, p < 0.001, and p = 0.03, respectively). Conclusions: In conclusion, this study demonstrates first time that some clinical characteristics of IDD have been associated with allele frequencies of VEGF −2549 I/D/ eNOS VNTR variants.



中文翻译:

VEGF 和 eNOS 变异可能影响椎间盘退变

摘要

背景:椎间盘退变 (IDD) 是一种常见且复杂的疾病。血管内皮生长因子(VEGF)是血管生成和血管通透性的关键调节因子之一。一氧化氮 (NO) 在各种生理事件中发挥作用。催化 NO 生成的内皮一氧化氮合酶 (eNOS) 对于 NO 水平的调节至关重要。本研究旨在评估 VEGF/eNOS 基因变异与 IDD 之间的关联。材料和方法:本病例对照研究包括 291 名受试者(111 名 IDD 患者和 180 名对照)。通过PCR方法分析VEGF -2549 插入/缺失(I/D)和eNOS VNTR变体。对该分析的结果进行了统计显着性评估。结果:IDD患者和对照受试者之间VEGF -2549 I/D/eNOS VNTR变体的基因型和等位基因分布没有统计学显着差异。然后,我们评估了这些变体的等位基因频率与 IDD 临床特征之间的关联。在携带 VEGF I/D 变异 D 等位基因的患者中,木材 IDD 更为常见(p < 0.001)。此外,腰椎间盘突出症、颈椎间盘突出症、腰椎管狭窄症和腰椎间盘突出症患者的 4 b 等位基因更多(分别为 p = 0.005、p < 0.001、p < 0.001 和 p = 0.03)。结论:总之,本研究首次证明 IDD 的一些临床特征与 VEGF -2549 I/D/eNOS VNTR 变体的等位基因频率相关。然后,我们评估了这些变体的等位基因频率与 IDD 临床特征之间的关联。在携带 VEGF I/D 变异 D 等位基因的患者中,木材 IDD 更为常见(p < 0.001)。此外,腰椎间盘突出症、颈椎间盘突出症、腰椎管狭窄症和腰椎间盘突出症患者的 4 b 等位基因更多(分别为 p = 0.005、p < 0.001、p < 0.001 和 p = 0.03)。结论:总之,本研究首次证明 IDD 的一些临床特征与 VEGF -2549 I/D/eNOS VNTR 变体的等位基因频率相关。然后,我们评估了这些变体的等位基因频率与 IDD 临床特征之间的关联。在携带 VEGF I/D 变异 D 等位基因的患者中,木材 IDD 更为常见(p < 0.001)。此外,腰椎间盘突出症、颈椎间盘突出症、腰椎管狭窄症和腰椎间盘突出症患者的 4 b 等位基因更多(分别为 p = 0.005、p < 0.001、p < 0.001 和 p = 0.03)。结论:总之,本研究首次证明 IDD 的一些临床特征与 VEGF -2549 I/D/eNOS VNTR 变体的等位基因频率相关。和腰椎 IDD 有更多的 4 b 等位基因(分别为 p = 0.005、p < 0.001、p < 0.001 和 p = 0.03)。结论:总之,本研究首次证明 IDD 的一些临床特征与 VEGF -2549 I/D/eNOS VNTR 变体的等位基因频率相关。和腰椎 IDD 有更多的 4 b 等位基因(分别为 p = 0.005、p < 0.001、p < 0.001 和 p = 0.03)。结论:总之,本研究首次证明 IDD 的一些临床特征与 VEGF -2549 I/D/eNOS VNTR 变体的等位基因频率相关。

更新日期:2022-07-05
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