Autologous matrix induced chondrogenesis plus peripheral blood concentrate (AMIC+PBC) in chondral lesions at the ankle as part of a complex surgical approach - 5-year follow-up,Foot and Ankle Surgery

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Autologous matrix induced chondrogenesis plus peripheral blood concentrate (AMIC+PBC) in chondral lesions at the ankle as part of a complex surgical approach - 5-year follow-up
Foot and Ankle Surgery ( IF 2.5 ) Pub Date : 2022-07-03 , DOI: 10.1016/j.fas.2022.06.015
Martinus Richter ₁ , Stefan Zech ₁ , Stefan Meissner ₁ , Issam Naef ₁

Affiliation

Background

The aim of the study was to assess 5-year-follow-up (5FU) after Autologous Matrix Induced Chondrogenesis plus Peripheral Blood Concentrate (AMIC+PBC) in chondral lesions at the ankle as part of a complex surgical approach.

Methods

In a prospective consecutive non-controlled clinical follow-up study, all patients with chondral lesion at the ankle treated with AMIC+PBC from July 17, 2016 to May 31, 2017 were included. Size and location of the chondral lesions, the Visual-Analogue-Scale Foot and Ankle (VAS FA) and the EFAS Score before treatment and at 5FU were analysed and compared with previous 2-year-follow-up (2FU). Peripheral Blood Concentrate (PBC) was used to impregnate a collagen I/III matrix (Chondro-Gide, Wolhusen, Switzerland) that was fixed into the chondral lesion with fibrin glue.

Results

One hundred and twenty-nine patients with 136 chondral lesions were included in the study. The chondral lesions were located as follows (n (%)), medial talar shoulder only, 62 (46); lateral talar shoulder only, 42 (31); medial and lateral talar shoulder, 7 (10); tibia, 18 (13). The average for lesion size was 1.8 cm², for VAS FA 45.7 and for EFAS Score 9.8. 2FU/5FU was completed in 105 (81 %)/104(81 %) patients with 112/111 previous chondral lesions. VAS FA improved to 79.8/84.2 and EFAS Score to 20.3/21.5 (2FU/5FU). No parameter significantly differed 2FU and 5FU.

Conclusions

AMIC+PBC as part of a complex surgical approach led to improved and high validated outcome scores at 2FU/5FU. 2FU and 5FU did not differ.

中文翻译：

自体基质诱导的软骨形成加上外周血浓缩物 (AMIC+PBC) 在踝关节软骨损伤中作为复杂手术方法的一部分 - 5 年随访

背景

该研究的目的是评估自体基质诱导软骨形成加外周血浓缩液 (AMIC+PBC) 作为复杂手术方法的一部分治疗脚踝软骨损伤后的 5 年随访 (5FU)。

方法

在一项前瞻性连续非对照临床随访研究中，纳入了 2016 年 7 月 17 日至 2017 年 5 月 31 日期间接受 AMIC+PBC 治疗的所有踝关节软骨损伤患者。分析软骨损伤的大小和位置、足踝视觉模拟量表 (VAS FA) 以及治疗前和 5FU 时的 EFAS 评分，并与之前的 2 年随访 (2FU) 进行比较。外周血浓缩物 (PBC) 用于浸渍胶原蛋白 I/III 基质（Chondro-Gide，Wolhusen，Switzerland），该基质用纤维蛋白胶固定到软骨损伤处。

结果

该研究包括 136 处软骨损伤的 129 名患者。软骨损伤位置如下（n（%）），仅内侧距骨肩部，62（46）；仅外侧距骨肩，42 (31)；内侧和外侧距骨肩，7 (10)；胫骨，18 (13)。病变大小的平均值为 1.8 cm ²，VAS FA 为 45.7，EFAS 评分为 9.8。105 (81 %)/104 (81 %) 名患者完成了 2FU/5FU，之前有 112/111 处软骨损伤。VAS FA 提高到 79.8/84.2，EFAS 评分提高到 20.3/21.5 (2FU/5FU)。2FU 和 5FU 的参数没有显着差异。