Aims/Introduction: Anemia is one of the common complications of diabetes mellitus (DM) and is associated with an increased risk of death. In recent years, phase angle (PhA) and the ratio of extracellular water to total body water (ECW/TBW) measured by bioelectrical impedance analysis (BIA) have been commonly used for estimating body composition. Since PhA and ECW/TBW have been reported to be useful as prognostic indicators for various chronic disease, we aimed to clarify the clinical significance of PhA and ECW/TBW in anemia of patients with DM. Materials and Methods: The values of PhA and ECW/TBW were measured by a portable BIA device (Inbody S10, Inbody Japan, Tokyo, Japan) and blood samples were collected in 403 Japanese patients with DM (217 males and 186 females) atAnan Medical Center, Tokushima Japan. The relationships of PhA and ECW/TBW with hematocrit (Ht) and hemoglobin (Hb) were statistically evaluated. Results: The level of PhA was decreased with age, whereas the value of ECW/TBW was increased with age. There was close inverse relationship between PhA and ECW/TBW (R2=0.7540, p< 0.001) . PhA was positively correlated with Hb and Ht levels (p <0.001, p <0.001, respectively) . In contrast, ECW/TBW was negatively correlated with Hb and Ht levels (p <0.001, p <0.001, respectively) . Multivariate regression analysis including confounding factors showed that both PhA and ECW/TBW independently contributed to Hb and Ht levels (p <0.0 and p <0.001, respectively) . Conclusions: PhA and ECW/TBW were associated with levels of Hb and Ht in patients with diabetes. The results suggest that BIA parameters reflect red blood cell lifespan and erythropoiesis. Disclosure T. Hori: None. H. Yamagami: None. S. Yasui: None. M. Hosoki: None. T. Hara: None. K. Kurahashi: None. S. Yoshida: None. M. Abe: None.

中文翻译：

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1504-PUB：全身生物电阻抗分析反映糖尿病患者的血红蛋白和血细胞比容水平

目的/简介：贫血是糖尿病 (DM) 的常见并发症之一，与死亡风险增加有关。近年来，通过生物电阻抗分析（BIA）测量的相位角（PhA）和细胞外水与全身水之比（ECW / TBW）已被普遍用于估计身体成分。由于据报道 PhA 和 ECW/TBW 可用作各种慢性疾病的预后指标，我们旨在阐明 PhA 和 ECW/TBW 在 DM 患者贫血中的临床意义。材料和方法：通过便携式 BIA 设备（Inbody S10，Inbody Japan，Tokyo，Japan）测量 PhA 和 ECW/TBW 的值，并在 Anan Medical 采集了 403 名日本 DM 患者（217 名男性和 186 名女性）的血液样本中心，德岛日本。统计评估PhA和ECW/TBW与血细胞比容（Ht）和血红蛋白（Hb）的关系。结果：PhA水平随年龄增长而降低，而ECW/TBW值随年龄增长而升高。PhA与ECW/TBW之间存在密切的反比关系（R2=0.7540，p＜0.001）。PhA 与 Hb 和 Ht 水平呈正相关（分别为 p <0.001，p <0.001）。相反，ECW/TBW 与 Hb 和 Ht 水平呈负相关（分别为 p <0.001，p <0.001）。包括混杂因素的多变量回归分析表明，PhA 和 ECW/TBW 均独立地影响 Hb 和 Ht 水平（分别为 p <0.0 和 p <0.001）。结论：PhA 和 ECW/TBW 与糖尿病患者的 Hb 和 Ht 水平相关。结果表明，BIA 参数反映了红细胞寿命和红细胞生成。披露 T. Hori：没有。H. Yamagami：没有。S. Yasui：没有。M. Hosoki：没有。T. Hara：没有。K.仓桥：没有。S.吉田：没有。M. Abe：没有。