Study question Are there differences between cases of ruptured and non-ruptured endometrioma? Summary answer Laboratory and clinical differences were detected between the patients who had surgery for ruptured endometrioma with the patients who had an unruptured endometrioma. What is known already Today, 20-50% of women with infertility problems have endometriosis. The incidence of endometrioma in patients with endometriosis is between 17-44%. Endometrioma is characterized by the presence of ectopic endometrial tissue in the form of cyst formation in the ovary. No value has yet been found to predict endometrioma rupture. Study design, size, duration Our study was conducted at Republic of Turkey Ministry of Health, Health Science University Etlik Zübeyde Hanım Gynecology Training and Research Hospital Infertility Clinic and all patients who were operated for endometrioma and had a histopathology report confirming the presence of endometrioma between January 2014 and December 2020 were included. It is a retrospective study. Participants/materials, setting, methods In this study, demographic characteristics, intraoperative findings, laboratory values and follow-up recommendations of two groups compared. The patients' age, presence of sexual activity or infertility, gravidity, abortion, accompanying systemic disease, operations, drug use, and symptoms were recorded. Preoperative and postoperative complete blood count, Cancer antigen125 (CA125), Cancer antigen19-9 (CA19-9), Cancer antigen15-3 (CA15-3), Carcinoembryonic antigen (CEA), alpha fetoprotein, anti mullerian hormone, fibrinogen, C-reactive protein (CRP) values of the patients were obtained. Main results and the role of chance The mean age of the patients recruited was 29.31±6.35(min:16-max:48). Endometrioma was intact in 146 (80.7%) of 181 patients, while endometrioma rupture was observed in 35 (19.3%) patients. C-reactive protein(p=.003), CA125(p<.001), CA19-9(p=.016), CA15-3(p=.001), CEA(p=.002) and MPV(mean platalet volume) values in the preoperative period of patients with rupture (p=.001) and postoperative CA125(p=.033), MPV(p=.001) and neutrofil/lymphocyte (NLR)(p=.034) values were found to be significantly higher than patients without rupture. The lymphocyte (p=.029) and eosinophil (p=.015) values in the postoperative period were found to be significantly lower than the patients without rupture. In our study, the rate of rupture in patients with sexual activity (11.9%) was found to be significantly lower than the rate of rupture (30.6%) in patients without sexual activity (p=.002). The rate of rupture in patients with a history of infertility (11.4%) was found to be significantly lower than the rate of rupture in patients without infertility (25.5%) (p=.017). In patients with a history of infertility, the duration of infertility in patients with rupture was found to be significantly lower than in patients without rupture (p=.006). The presence of accompanying pathology in ruptured patients was found to be 30 (52.6%) significantly higher than 5 (4.1%) rupture cases without additional pathology (p<.001). Limitations, reasons for caution The limitations of the study are the retrospective design, the evaluation of only patients who have undergone surgery, and it was performed in a single center. Wider implications of the findings Our study has the largest sample size and includes details not found in other studies in the literature, with a detailed examination of the patients' data. We think that our study will make important contributions to the literature in predicting endometrioma rupture. Trial registration number 2021/76

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P-328 手术破裂和未破裂子宫内膜异位症的比较

研究问题 破裂和未破裂的子宫内膜异位症病例之间是否存在差异？总结回答 在因子宫内膜异位症破裂而进行手术的患者与未破裂子宫内膜异位症患者之间检测到实验室和临床差异。已知情况 今天，20-50% 患有不孕症的女性患有子宫内膜异位症。子宫内膜异位症患者子宫内膜异位症的发病率在 17-44% 之间。子宫内膜异位症的特征在于卵巢中存在以囊肿形式存在的异位子宫内膜组织。尚未发现预测子宫内膜异位瘤破裂的价值。研究设计、规模、持续时间 我们的研究是在土耳其共和国卫生部进行的，健康科学大学 Etlik Zübeyde Hanım 妇科培训和研究医院不孕症诊所以及所有在 2014 年 1 月至 2020 年 12 月期间接受子宫内膜异位症手术并有组织病理学报告证实存在子宫内膜异位症的患者都被纳入研究。这是一项回顾性研究。参与者/材料、设置、方法 在本研究中，比较了两组的人口统计学特征、术中发现、实验室值和随访建议。记录患者的年龄、有无性行为或不孕、妊娠、流产、伴随的全身性疾病、手术、药物使用和症状。术前术后全血细胞计数、癌抗原125（CA125）、癌抗原19-9（CA19-9）、癌抗原15-3（CA15-3）、癌胚抗原（CEA）、甲胎蛋白、获得患者的抗苗勒管激素、纤维蛋白原、C反应蛋白（CRP）值。主要结果和机会的作用 招募患者的平均年龄为29.31±6.35（最小：16-最大：48）。181 名患者中有 146 名（80.7%）子宫内膜瘤完好无损，而 35 名（19.3%）患者中观察到子宫内膜瘤破裂。C-反应蛋白(p=.003)、CA125(p<.001)、CA19-9(p=.016)、CA15-3(p=.001)、CEA(p=.002) 和 MPV(平均破裂患者术前 (p=.001) 和术后 CA125 (p=.033)、MPV (p=.001) 和中性粒细胞/淋巴细胞 (NLR) (p=.034) 的血小板体积值分别为发现明显高于没有破裂的患者。发现术后淋巴细胞 (p=.029) 和嗜酸性粒细胞 (p=.015) 值显着低于未破裂的患者。在我们的研究中，发现有性活动的患者的破裂率 (11.9%) 明显低于没有性活动的患者的破裂率 (30.6%) (p=.002)。有不孕史患者的破裂率（11.4%）明显低于无不孕症患者的破裂率（25.5%）（p=.017）。在有不孕史的患者中，破裂患者的不孕持续时间显着低于未破裂患者（p=.006）。发现破裂患者中伴随病理的存在显着高于 30 例（52.6%），显着高于 5 例（4.1%）没有其他病理的破裂病例（p<.001）。局限性，谨慎的原因 该研究的局限性是回顾性设计，仅对接受过手术的患者进行评估，并在一个中心进行。研究结果的更广泛意义 我们的研究拥有最大的样本量，包括文献中其他研究中未发现的细节，并详细检查了患者的数据。我们认为我们的研究将对预测子宫内膜异位症破裂的文献做出重要贡献。试用注册号 2021/76