Mesonephric-like adenocarcinomas (MLA) are rare neoplasms arising in the cervix, endometrium, and ovary. In contrast to mesonephric carcinomas (MC), mesonephric-like adenocarcinomas are not associated with mesonephric remnants. Both entities have a similar appearance with regards to varying histomorphology patterns, including glandular, tubular, spindled, solid, and papillary, and have a specific immunophenotype and molecular features. We present a case of a 54-year-old HPV-negative woman with a Pap test that exhibits high-grade malignancy. The cell block displayed malignant cells with positive stains for PAX8, GATA3, and TTF1 by immunohistochemistry. The diagnosis of adenocarcinoma with mesonephric like features was rendered. MLA can be challenging on the small specimens and often misinterpreted as other endometrial neoplasms. Furthermore, the accurate diagnosis carries a well-described risk of aggressive clinical behavior.

中文翻译：

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子宫颈巴氏涂片检查诊断为具有中肾样特征和梭形细胞成分的不寻常癌病例：细胞形态学和免疫表型特征和诊断缺陷

中肾样腺癌 (MLA) 是发生于子宫颈、子宫内膜和卵巢的罕见肿瘤。与中肾癌 (MC) 相比，中肾样腺癌与中肾残余无关。这两种实体在不同的组织形态学模式方面具有相似的外观，包括腺体、管状、梭形、实性和乳头状，并具有特定的免疫表型和分子特征。我们介绍了一名 54 岁 HPV 阴性女性的病例，其巴氏试验显示为高度恶性肿瘤。细胞块显示恶性细胞，免疫组化 PAX8、GATA3 和 TTF1 染色阳性。诊断为具有中肾样特征的腺癌。MLA 在小样本上可能具有挑战性，并且经常被误解为其他子宫内膜肿瘤。此外，