We thank S. Couillard for his interesting comments related to our publication on the effects of interleukin (IL)-5 deficiency on the transcriptome of residual eosinophils of Il5-deficient mice and mepolizumab-treated patients [1]. We indeed document stronger upregulation of the expression of the SOCS3 gene following stimulation with IL-33 ex vivo that is conserved between eosinophils from mepolizumab-treated patients and from Il5-deficient mice.

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回复：美泊利单抗治疗患者嗜酸性粒细胞中的离体 SOCS3 基因对警报素的反应尚无生物学意义

我们感谢 S. Couillard 就我们发表的关于白介素 (IL)-5 缺乏对Il5 缺陷小鼠和美泊利单抗治疗患者的残留嗜酸性粒细胞转录组的影响发表的有趣评论 [1]。我们确实记录了在用来自美泊利单抗治疗的患者和来自Il5 缺陷小鼠的嗜酸性粒细胞之间保守的离体IL-33 刺激后 SOCS3 基因表达的更强上调。