Ewing's sarcoma (ES) is an aggressive malignant tumor commonly affecting adolescents. The standard of care includes surgical treatment and systemic therapies, although ES patients often develop drug resistance, leading to disease progression. Tumorigenesis in Ewing's sarcoma has unique characteristics that allow for the development of targeted therapeutics. New data on the role of oncogenic drivers in ES tumorigenesis, particularly in relation to treatment-induced stress, offers new therapeutic opportunities. This review summarizes the latest information on the clinically relevant oncogenes found in Ewing's sarcoma, their biological roles, and candidate targets for improving ES patient outcomes.

尤文氏肉瘤 (ES) 是一种侵袭性恶性肿瘤，通常影响青少年。护理标准包括手术治疗和全身治疗，尽管 ES 患者经常产生耐药性，导致疾病进展。尤文氏肉瘤的肿瘤发生具有独特的特征，可以开发靶向治疗。关于致癌驱动因素在 ES 肿瘤发生中作用的新数据，特别是与治疗引起的压力有关，提供了新的治疗机会。本综述总结了尤文肉瘤中发现的临床相关癌基因的最新信息，它们的生物学作用，以及改善 ES 患者预后的候选靶点。