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Analytical Methods for Furanochromone Natural Product, Khellin and Its Inspired Drug Candidates, Amiodarone and Sodium Cromoglycate
Critical Reviews in Analytical Chemistry ( IF 5 ) Pub Date : 2022-07-01 , DOI: 10.1080/10408347.2022.2094198
Raj P Shah 1 , Sonali S Bharate 1
Affiliation  

Abstract

Khellin is the key furanocoumarin of Ammi visnaga L. (Lam.) that exhibits various biological properties. This unique natural product has inspired the discovery of two first-in-class drugs, amiodarone and sodium cromoglycate. A wide range of analytical methods were generated while translating khellin scaffold into clinically used drugs; however, they have never been reviewed and critically assessed. The present review aims to review and evaluate the analytical techniques for the natural products, khellin, visnagin, and their inspired drugs, amiodarone and sodium cromoglycate. High-performance liquid chromatography (HPLC) is the extensively used technique in most analytical methods reported for these compounds; however, other techniques including the fluorimetry, luminescence spectrophotometry, potentiometry, voltammetry, FT-Raman spectroscopy, and ELISA were also employed. The review will be helpful for further basic and translational research on furanochromone and related scaffolds.



中文翻译:

呋喃色酮天然产物、Khellin 及其受启发的候选药物胺碘酮和色甘酸钠的分析方法

摘要

Khellin 是Ammi visnaga的主要呋喃香豆素L. (Lam.) 具有多种生物学特性。这种独特的天然产物激发了两种一流药物胺碘酮和色甘酸钠的发现。在将khellin支架转化为临床使用的药物时,产生了广泛的分析方法;但是,它们从未经过审查和严格评估。本综述旨在回顾和评估天然产物、khellin、visnagin 及其启发药物胺碘酮和色甘酸钠的分析技术。高效液相色谱法 (HPLC) 是这些化合物报告的大多数分析方法中广泛使用的技术。然而,也采用了其他技术,包括荧光法、发光分光光度法、电位法、伏安法、FT-拉曼光谱法和 ELISA。

更新日期:2022-07-03
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