Postural orthostatic tachycardia syndrome (POTS), first described in 1992, remains an enigmatic, yet severely and variably debilitating, disorder. The pathophysiology of this syndrome is still not understood, and there remains no biomarker indicating the presence of POTS. Although research interest has increased in recent years, there are relatively fewer clinical and research studies addressing POTS in children and adolescents compared with adults. Yet, adolescence is when a large number of cases of POTS begin, even among adult patients who are subsequently studied. This article summarizes reported research in POTS, specifically in pediatric patients, including discussion of aspects of diagnostic criteria, risk factors and outcomes, neurohormonal and hemodynamic abnormalities, clinical assessment, and treatment. The goals of this review are increased recognition and acknowledgment of POTS among pediatric and adolescent providers, as well as to provide an understanding of reported abnormalities of homeostasis, such that symptomatic patients will be able to be recognized and appropriately managed, enabling them to return to their activities of daily living.

中文翻译：

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小儿体位性心动过速综合征：我们的立场。

1992 年首次描述的体位性体位性心动过速综合征 (POTS) 仍然是一种神秘的、但严重且多变的使人衰弱的疾病。该综合征的病理生理学仍不清楚，也没有表明存在 POTS 的生物标志物。尽管近年来研究兴趣有所增加，但与成人相比，针对儿童和青少年 POTS 的临床和研究研究相对较少。然而，青春期是大量 POTS 病例开始的时候，即使在随后研究的成年患者中也是如此。本文总结了已报道的 POTS 研究，特别是在儿科患者中的研究，包括对诊断标准、风险因素和结果、神经激素和血流动力学异常、临床评估和治疗等方面的讨论。