Objective: 

Unexplained regression in Down syndrome (URDS) involves a loss of acquired skills resulting in functional deterioration. Despite extensive workup and treatment, few individuals regain baseline function. This study aimed to understand the role of psychosocial stressors in URDS.

Methods: 

We describe psychosocial stressors in 14 cases of URDS. Specifically, we examined psychosocial stressors in the context of presentation and clinical symptoms. We also examined co-occurring neurodevelopmental disorders and medical and mental health conditions.

Results: 

All individuals experienced psychosocial stressors within one year of diagnosis of URDS. The most common psychosocial stressors were moving to a new home or school.

Conclusion: 

Psychosocial stressors are commonly reported preceding URDS. Knowledge about psychosocial stressors' impact may lead to preventive interventions, improved monitoring, and earlier diagnosis. Future research should focus on understanding psychosocial stressors to help identify individuals at risk for URDS and contribute to treatment.

中文翻译：

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唐氏综合症的发育退化与生活压力有关吗？

客观的： 

唐氏综合症 (URDS) 的不明原因退化涉及习得技能的丧失，导致功能恶化。尽管进行了大量的检查和治疗，但很少有人恢复基线功能。本研究旨在了解社会心理压力源在 URDS 中的作用。

方法： 

我们描述了 14 例 URDS 病例中的社会心理压力源。具体来说，我们在表现和临床症状的背景下检查了心理社会压力源。我们还检查了同时发生的神经发育障碍以及医疗和心理健康状况。

结果： 

所有个体在诊断 URDS 后一年内都经历过心理社会压力。最常见的社会心理压力源是搬到新家或学校。

结论： 

社会心理压力源通常出现在 URDS 之前。了解心理社会压力源的影响可能会导致预防性干预、改进监测和早期诊断。未来的研究应侧重于了解社会心理压力源，以帮助识别有 URDS 风险的个体并有助于治疗。