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Proof of concept of a two-stage GMR sensor-based lab-on-a-chip for early diagnostic tests
Lab on a Chip ( IF 6.1 ) Pub Date : 2022-06-30 , DOI: 10.1039/d2lc00353h
Maïkane Deroo 1, 2 , Manon Giraud 1, 2 , François-Damien Delapierre 1 , Pierre Bonville 1 , Mathieu Jeckelmann 1 , Aurélie Solignac 1 , Elodie Fabre-Paul 1 , Mathieu Thévenin 1 , Frédéric Coneggo 1 , Claude Fermon 1 , Florent Malloggi 3 , Stéphanie Simon 2 , Cécile Féraudet-Tarisse 2 , Guénaëlle Jasmin-Lebras 1
Affiliation  

The development of rapid, sensitive, portable and inexpensive early diagnostic techniques is a real challenge in the fields of health, defense and in the environment. The current global pandemic has also shown the need for such tests. The World Health Organization has defined ASSURED criteria (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free and deliverable to end-users) that field diagnostic tests must fulfill, which proves the real need in terms of public health. Giant magnetoresistance (GMR) sensors, which have flourished in a wide variety of spintronic applications (automobile industry, Information Technology, etc.), also have real potential in the field of health, particularly for the development of early diagnostic point-of-care devices. This work presents a new type of innovative biochip, consisting of GMR sensors arranged on both sides of a microfluidic channel which allow on the one hand to count magnetic objects one by one but also to better distinguish false positives (aggregates of beads, etc.) from labelled biological targets of interest by determining their magnetic moment. We present the operating principle of this new tool and its great potential as a versatile diagnostic test.

中文翻译:

用于早期诊断测试的基于两级 GMR 传感器的片上实验室的概念验证

快速、灵敏、便携和廉价的早期诊断技术的发展是健康、国防和环境领域的真正挑战。当前的全球大流行也表明需要进行此类测试。世界卫生组织定义了现场诊断测试必须满足的 ASSURED 标准(价格合理、敏感、具体、用户友好、快速和稳健、无需设备且可交付给最终用户),这证明了公共卫生方面的真正需求. 巨磁阻 (GMR) 传感器在各种自旋电子应用(汽车工业、信息技术等)中蓬勃发展。),在健康领域也具有真正的潜力,特别是在开发早期诊断点护理设备方面。这项工作提出了一种新型的创新生物芯片,由布置在微流体通道两侧的 GMR 传感器组成,一方面可以对磁性物体进行逐个计数,而且可以更好地区分误报(珠子的聚集体) 。通过确定它们的磁矩来从标记的感兴趣的生物目标中提取。我们介绍了这种新工具的工作原理及其作为多功能诊断测试的巨大潜力。
更新日期:2022-07-01
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