PURPOSE To investigate the protective effect of penehyclidine hydrochloride (PHC) on cardiopulmonary bypass (CPB)-related lung injury in rats. METHODS Thirty-six rats were divided into control, CPB and PHC groups. The CPB model was established in CPB and PHC groups. In PHC group, 2-mg/kg PHC was added to the pre-filling solution for CPB modeling. At 30 min before CPB (T1), immediately after left hilar opening (T2) and end of experiment (T3), the hemodynamic indexes, blood gas indexes, serum inflammatory factors, lung wet-day ratio and water content and lung tissue oxidative stress indexes were determined. RESULTS At T2 and T3, compared with CPB group, in PHC group the heart rate and mean arterial pressure increased significantly, the oxygenation index increased significantly, the respiratory index decreased significantly, and the lung wet-day ratio and water content decreased significantly. At T3, compared with CPB group, in PHC groups the serum tumor necrosis factor α, interleukin 6 and interleukin 1β levels decreased significantly, the lung tissue superoxide dismutase level increased significantly, and the myeloperoxidase and malondialdehyde levels decreased significantly. CONCLUSIONS PHC treatment can alleviate the CPB-related lung injury in rats. The mechanisms may be related to its reducing inflammatory response and resisting oxidative stress.

中文翻译：

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盐酸戊乙奎醚对体外循环相关性肺损伤大鼠炎症反应和氧化应激的影响。

目的探讨盐酸戊乙奎醚（PHC）对大鼠体外循环（CPB）相关肺损伤的保护作用。方法 36只大鼠分为对照组、CPB组和PHC组。CPB模型建立在CPB组和PHC组。在 PHC 组中，将 2-mg/kg PHC 添加到 CPB 建模的预填充溶液中。CPB前30 min（T1）、左肺门开口后（T2）、实验结束后（T3），血流动力学指标、血气指标、血清炎性因子、肺湿日比和含水量及肺组织氧化应激指标确定。结果T2、T3时，与CPB组相比，PHC组心率和平均动脉压明显升高，氧合指数明显升高，呼吸指数明显下降，肺湿日比和含水量明显下降。T3时，与CPB组相比，PHC组血清肿瘤坏死因子α、白细胞介素6和白细胞介素1β水平明显下降，肺组织超氧化物歧化酶水平明显升高，髓过氧化物酶和丙二醛水平明显下降。结论 PHC治疗可减轻大鼠CPB相关肺损伤。其机制可能与其减少炎症反应和抵抗氧化应激有关。髓过氧化物酶和丙二醛水平显着下降。结论 PHC治疗可减轻大鼠CPB相关肺损伤。其机制可能与其减少炎症反应和抵抗氧化应激有关。髓过氧化物酶和丙二醛水平显着下降。结论 PHC治疗可减轻大鼠CPB相关肺损伤。其机制可能与其减少炎症反应和抵抗氧化应激有关。