Striatal Blood–Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study,Movement Disorders

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Striatal Blood–Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study
Movement Disorders ( IF 8.6 ) Pub Date : 2022-06-28 , DOI: 10.1002/mds.29134
José A Pineda-Pardo _{1,

2,

3} , Carmen Gasca-Salas _{1,

2,

3} , Beatriz Fernández-Rodríguez _{1,

4} , Rafael Rodríguez-Rojas _{1,

2} , Marta Del Álamo ₁ , Ignacio Obeso _{1,

2} , Frida Hernández-Fernández ₁ , Clara Trompeta ₁ , Raúl Martínez-Fernández _{1,

2} , Michele Matarazzo _{1,

2} , David Mata-Marín ₁ , Pasqualina Guida ₁ , Alicia Duque ₅ , David Albillo ₅ , Isabel Plaza de Las Heras ₆ , Juan I Montero ₇ , Guglielmo Foffani _{1,

2,

8} , Gabriella Toltsis ₉ , Itay Rachmilevitch ₉ , Javier Blesa _{1,

2} , José A Obeso _{1,

2,

3}

Affiliation

Parkinson's disease (PD) exhibits a high prevalence of dementia as disease severity and duration progress. Focused ultrasound (FUS) has been applied for transient blood–brain barrier (BBB) opening of cortical regions in neurodegenerative disorders. The striatum is a primary target for delivery of putative therapeutic agents in PD.

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