Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: A systematic review and meta-analysis,Osteoporosis International

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Relationship between prevalence and risk of osteoporosis or osteoporotic fracture with non-alcoholic fatty liver disease: A systematic review and meta-analysis
Osteoporosis International ( IF 4 ) Pub Date : 2022-06-28 , DOI: 10.1007/s00198-022-06459-y
Binjing Pan ₁ , Jing Cai ₁ , Pingping Zhao ₁ , Jingfang Liu _{1,

2} , Songbo Fu _{1,

2} , Gaojing Jing _{1,

2} , Qianglong Niu _{1,

2} , Qiong Li _{1,

2}

Affiliation

Summary

The aim of this study was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and NAFLD. Patients with NAFLD should be monitored regularly for bone mineral density and bone metabolism indicators to prevent osteoporosis or osteoporotic fractures.

Objectives

The aim of this meta-analysis was to investigate the relationship between prevalence and risks of osteoporosis or osteoporotic fracture and non-alcoholic fatty liver disease (NAFLD).

Methods

Five databases, including PubMed, Web of Science, Embase, Scopus and Cochrane Library, were searched since the conception of these databases until December 2021. The cohort studies, cross-sectional analyses or case–control studies evaluating the relationship between osteoporosis or osteoporotic fracture and NAFLD were retrieved from these databases. Relevant data were extracted from the included studies, and a meta-analysis was performed.

Results

A total of seven studies were included. The prevalence of osteoporosis or osteoporotic fractures was higher in the NAFLD group than in the non-NAFLD group [OR = 1.17, 95%CI(1.04,1.31)], while the prevalence of osteoporosis was higher in the NAFLD group than in the non-NAFLD group [OR = 1.46, 95%CI (1.21,1.77) and OR = 1.48, 95%CI (1.31,1.68), respectively] in men and women. The risk of osteoporosis or osteoporotic fractures was higher in the NAFLD group than in the non-NAFLD group [OR = 1.33,95%CI (1.24,1.44) and OR = 1.57,95%CI (1.08,2.29), respectively]. The risk of osteoporosis or osteoporotic fractures was higher in male and female NAFLD groups than that in the non-NAFLD group [OR = 1.29, 95%CI(1.14,1.47) and OR = 1.36, 95%CI (1.25,1.48), respectively]. After parameter adjustment, the risk of osteoporosis or osteoporotic fracture was higher in the male NAFLD group than in the non-NAFLD group [OR = 2.10, 95%CI(1.36,3.25)], while no significant difference was found among women [OR = 1.13, 95%CI (0.86,1.48)].

Conclusions

The prevalence and risk of osteoporosis or osteoporotic fractures were significantly associated with NAFLD in men and women.

Trial registration: PROSPERO 2022 CRD42022304708

中文翻译：

骨质疏松症或骨质疏松性骨折合并非酒精性脂肪肝的患病率与风险之间的关系：系统评价和荟萃分析

概括

本研究的目的是调查骨质疏松症或骨质疏松性骨折与 NAFLD 的患病率和风险之间的关系。应定期监测 NAFLD 患者的骨密度和骨代谢指标，以预防骨质疏松或骨质疏松性骨折。

目标

这项荟萃分析的目的是调查骨质疏松症或骨质疏松性骨折与非酒精性脂肪肝病 (NAFLD) 的患病率和风险之间的关系。

方法

从这些数据库的概念到 2021 年 12 月，包括 PubMed、Web of Science、Embase、Scopus 和 Cochrane Library 在内的五个数据库进行了搜索。队列研究、横断面分析或病例对照研究评估了骨质疏松症或骨质疏松性骨折之间的关系从这些数据库中检索到 NAFLD 和 NAFLD。从纳入的研究中提取相关数据，并进行荟萃分析。

结果

共纳入七项研究。NAFLD 组骨质疏松或骨质疏松性骨折的患病率高于非 NAFLD 组 [OR = 1.17, 95%CI(1.04,1.31)]，而 NAFLD 组的骨质疏松患病率高于非 NAFLD 组。 -NAFLD 组 [OR = 1.46, 95%CI (1.21,1.77) 和 OR = 1.48, 95%CI (1.31,1.68)]，男性和女性。NAFLD 组发生骨质疏松或骨质疏松性骨折的风险高于非 NAFLD 组 [OR = 1.33,95%CI (1.24,1.44) 和 OR = 1.57,95%CI (1.08,2.29)]。男性和女性 NAFLD 组发生骨质疏松或骨质疏松性骨折的风险高于非 NAFLD 组 [OR = 1.29, 95%CI(1.14,1.47) 和 OR = 1.36, 95%CI (1.25,1.48),分别]。参数调整后，