Background

Several retrospective studies on pediatric epilepsy reported positive effects of cannabidiol-enriched artisanal cannabis oil and pure cannabidiol oil on seizure reduction.

Methods

This is a retrospective study of children and adolescents with refractory epilepsy caused by various etiologies who were treated with artisanal cannabis oil during January 2014 to June 2019, with at least one year follow-up.

Results

Of 114 patients, 84 (73.3%) reported some improvement in seizure frequency at some point during treatment. Fifty-one (59%) of the 86 patients who continued treatment for at least one year showed >50% improvement in seizure frequency. Seizure etiology, seizure type, and patients' age and sex were not found to be associated with the response to cannabidiol-enriched cannabis oil. Side effects were minor, and positive effects beyond seizure reduction were noted.

Conclusions

Artisanal cannabidiol-enriched cannabis may be an effective and safe long-term treatment for refractory epilepsy.

中文翻译：

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富含大麻二酚的油在儿童耐药性癫痫中的长期有效性和安全性

背景

几项关于小儿癫痫的回顾性研究报告了富含大麻二酚的手工大麻油和纯大麻二酚油对减少癫痫发作的积极作用。

方法

这是一项对 2014 年 1 月至 2019 年 6 月期间接受手工大麻油治疗的各种病因引起的难治性癫痫儿童和青少年的回顾性研究，至少随访一年。

结果

在 114 名患者中，84 名 (73.3%) 报告在治疗期间的某个时间点癫痫发作频率有所改善。在持续治疗至少一年的 86 名患者中，有 51 名 (59%) 的癫痫发作频率改善了 >50%。没有发现癫痫发作的病因、癫痫发作类型以及患者的年龄和性别与对富含大麻二酚的大麻油的反应有关。副作用很小，并且注意到除了减少癫痫发作之外的积极作用。

结论

手工富含大麻二酚的大麻可能是治疗难治性癫痫的有效且安全的长期治疗方法。