Episodes of lucidity (ELs) in Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD), have garnered increasing attention as an important area of research. Efforts to study lucidity suffer from a lack of clear definitional criteria, inconsistent conceptualization, and diverse approaches to operationalizing features of these events. To advance systematic investigation of ELs in AD/ADRD, there is a need for clarity and precision in labeling event attributes, markers, and specific measurement strategies that enable operational harmonization across distinct approaches to investigating the relatively broad and nascent phenomenon. To that end, we propose a preliminary research framework to guide harmonization of approaches to investigating ELs in AD/ADRD. Our goal is to provide an initial schematic that encourages uniform labeling of operational decisions about ELs.

中文翻译：

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协调研究 AD/ADRD 清醒度的策略：初步研究框架

阿尔茨海默病和阿尔茨海默病相关痴呆 (AD/ADRD) 中的清醒发作 (EL) 作为一个重要的研究领域受到越来越多的关注。研究清醒度的努力因缺乏明确的定义标准、概念化不一致以及操作这些事件的特征的不同方法而受到影响。为了推进对 AD/ADRD 中 EL 的系统研究，需要清晰和精确地标记事件属性、标记和特定的测量策略，以实现跨不同方法的操作协调，以调查相对广泛和新生的现象。为此，我们提出了一个初步研究框架，以指导协调在 AD/ADRD 中调查 EL 的方法。