Summary

In an Ontario fracture liaison service (FLS), we compared medication prescription rates among patients not taking a previously prescribed bone active medication to those with no previous prescription. Prescription rates were similar between these two groups of patients. The FLS provided a secondary opportunity for patients to initiate bone active medication.

Purpose

We compared bone active medication prescription rates among patients presenting to an Ontario fracture liaison service (FLS) who reported not taking a previously prescribed bone active medication to those with no history of prescription.

Methods

Eligible patients were those screened in 39 fracture clinics between July 1, 2017, and September 15, 2019, who were not taking bone active medication at the time of screening and classified as high risk for future fracture based on CAROC or FRAX. Sociodemographic and clinical risk factor variables were assessed at screening. Bone active medication prescription rate was assessed within 6 months of screening and defined as having received a prescription for the medication from either a specialist or primary care provider. In cases where a specialist report was not available, patient self-reported data were collected. The chi-square test of independence was used to assess differences in prescription rates.

Results

Of 17,575 patients screened, eligible patients were 350 with a previous prescription and 2644 without a previous prescription. Compared with patients who reported no previous prescription, those who had a previous prescription were older, more likely to be female and to report a previous fracture, and less likely to smoke. There was no statistically significant difference between the medication prescription rate of patients with a previous prescription (73.7%) compared to patients with no previous prescription (70.7%) (p = 0.157).

Conclusion

A large jurisdiction-wide FLS approach provided a secondary opportunity to patients who were not taking a previously prescribed bone active medication to initiate that medication.

中文翻译：

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未服用以前处方的骨活性药物的患者现在通过安大略省 FLS 处方药物

概括

在安大略省骨折联络服务 (FLS) 中，我们比较了未服用先前处方的骨活性药物与未服用先前处方的患者的药物处方率。这两组患者的处方率相似。FLS 为患者提供了启动骨活性药物治疗的第二次机会。

目的

我们比较了在安大略骨折联络服务 (FLS) 就诊且报告未服用过先前处方的骨活性药物的患者与没有处方史的患者的骨活性药物处方率。

方法

符合条件的患者是 2017 年 7 月 1 日至 2019 年 9 月 15 日期间在 39 家骨折诊所接受筛查的患者，他们在筛查时未服用骨活性药物，并根据 CAROC 或 FRAX 分类为未来骨折的高风险。在筛选时评估社会人口统计学和临床​​危险因素变量。骨活性药物处方率在筛选后 6 个月内进行评估，并定义为已从专家或初级保健提供者处获得药物处方。在没有专家报告的情况下，收集患者自我报告的数据。独立性卡方检验用于评估处方率的差异。

结果

在筛选的 17,575 名患者中，符合条件的患者有 350 名以前有过处方，2644 名没有以前有过处方。与报告之前没有处方的患者相比，之前有处方的患者年龄更大，更有可能是女性并且报告之前有骨折，并且不太可能吸烟。有既往处方的患者（73.7%）与未开具处方的患者（70.7%）的药物处方率差异无统计学意义（p  = 0.157）。

结论

一个大型的全辖区 FLS 方法为未服用先前规定的骨活性药物的患者提供了第二次机会来启动该药物。