Vascular interventions are a promising application of Magnetic Particle Imaging enabling a high spatial and temporal resolution without using ionizing radiation. The possibility to visualize the vessels as well as the devices, especially at the same time using multi-contrast approaches, enables a higher accuracy for diagnosis and treatment of vascular diseases. Different techniques to make devices MPI visible have been introduced so far, such as varnish markings or filling of balloons. However, all approaches include challenges for in vivo applications, such as the stability of the varnishing or the visibility of tracer filled balloons in deflated state. In this contribution, we present for the first time a balloon catheter that is molded from a granulate incorporating nanoparticles and can be visualized sufficiently in MPI. Computed tomography is used to show the homogeneous distribution of particles within the material. Safety measurements confirm that the incorporation of nanoparticles has no negative effect on the balloon. A dynamic experiment is performed to show that the inflation as well as deflation of the balloon can be imaged with MPI.

中文翻译：

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第一条用于磁粉成像的专用球囊导管

血管介入是磁粒子成像的一个很有前途的应用，它可以在不使用电离辐射的情况下实现高空间和时间分辨率。血管和设备可视化的可能性，尤其是同时使用多对比方法，可以提高血管疾病诊断和治疗的准确性。到目前为止，已经引入了使设备 MPI 可见的不同技术，例如清漆标记或气球填充。然而，所有方法都包含对体内应用的挑战，例如清漆的稳定性或放气状态下示踪剂填充气球的可见性。在此贡献中，我们首次展示了一种球囊导管，它由包含纳米颗粒的颗粒模制而成，并且可以在 MPI 中充分可视化。计算机断层扫描用于显示材料中颗粒的均匀分布。安全测量证实纳米颗粒的加入对气球没有负面影响。执行动态实验以表明可以使用 MPI 对气球的充气和放气进行成像。